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首页> 外文期刊>Biochemistry >Signal Recognition Particle (SRP) and SRP Receptor: A New Paradigm for Multistate Regulatory GTPases
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Signal Recognition Particle (SRP) and SRP Receptor: A New Paradigm for Multistate Regulatory GTPases

机译：信号识别粒子（SRP）和SRP受体：多态监管GTPases的新范例

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摘要

The GTP-binding proteins or GTPases comprise a superfamily of proteins that provide molecularnswitches in numerous cellular processes. The “GTPase switch” paradigm, in which aGTPase acts as a bimodalnswitch that is turned “on” and “off” by external regulatory factors, has been used to interpret the regulatorynmechanism of many GTPases for more than two decades. Nevertheless, recent work has unveiled an emergingnclass of “multistate” regulatory GTPases that do not adhere to this classical paradigm. Instead of relying onnexternal nucleotide exchange factors or GTPase activating proteins to switch between the on and off states,nthese GTPases have the intrinsic ability to exchange nucleotides and to sense and respond to upstream andndownstream factors. In contrast to the bimodal nature of the GTPase switch, these GTPases undergo multiplenconformational rearrangements, allowing multiple regulatory points to be built into a complex biologicalnprocess to ensure the efficiency and fidelity of the pathway. We suggest that these multistate regulatorynGTPases are uniquely suited to provide spatial and temporal control of complex cellular pathways thatnrequire multiple molecular events to occur in a highly coordinated fashion.
机译：GTP结合蛋白或GTP酶包含一个蛋白质超家族，可在众多细胞过程中提供分子开关。在过去的二十多年中，“ GTPase开关”范式（其中aGTPase充当双峰开关）通过外部调节因素“打开”和“关闭”，已被用来解释许多GTPases的调节机制。尽管如此，最近的工作还是揭示了一种新兴的“多状态”监管GTPases类，它不符合这种经典范式。这些GTPases不需要依赖非内部核苷酸交换因子或GTPase活化蛋白在开和关状态之间切换，而是具有交换核苷酸以及感知和响应上游和下游因子的内在能力。与GTPase开关的双峰性质相反，这些GTPases经历了多重构象重排，从而允许将多个调节点构建到复杂的生物过程中，以确保该途径的效率和保真度。我们建议这些多状态调节nGTPases独特地适合提供复杂细胞途径的空间和时间控制，这些细胞途径不需要以高度协调的方式发生多个分子事件。

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  • 来源
    《Biochemistry》 |2009年第29期|p.6696-6704|共9页
  • 作者

    Shu-ou Shan Sandra L. Schmid and Xin Zhang;

  • 作者单位

    ‡Division of Chemistry and Chemical Engineering, California Institute of Technology, 1200 East California Boulevard, Pasadena,California 91125, and §Department of Cell Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla,California 92037;

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