Crystal Structure of an Archaeal Rad51 Homologue in Complex with a Metatungstate Inhibitor

Yang Li Yujiong He and Yu Luo

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Crystal Structure of an Archaeal Rad51 Homologue in Complex with a Metatungstate Inhibitor

机译：古代细菌Rad51同系物与偏钨酸盐抑制剂的复杂的晶体结构。

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Archaeal RadAs are close homologues of eukaryal Rad51s (∼40% sequence identities). Thesenrecombinases promote a hallmark strand exchange process between homologous single-stranded and doublestrandednDNA substrates. This DNA-repairing function also plays a key role in cancer cells’ resistance tonchemo- and radiotherapy. Inhibition of the strand exchange process may render cancer cells more susceptiblento therapeutic treatment. We found that metatungstate is a potent inhibitor of RadA from Methanococcusnvoltae. The tungsten cluster binds RadA in the axial DNA-binding groove. This polyanionic species appearsnto inhibit RadA by locking the protein in its inactive conformation.

机译：古细菌RadAs是真核Rad51s的紧密同源物（约40％序列同一性）。 senrecombinases促进同源单链和双链nDNA底物之间的标志链交换过程。这种DNA修复功能在癌细胞对支气管和放射疗法的抵抗中也起着关键作用。链交换过程的抑制可能使癌细胞更易于接受治疗。我们发现，偏钨酸盐是甲烷球菌的有效的RadA抑制剂。钨簇在轴向DNA结合槽中结合RadA。该聚阴离子物质似乎通过将蛋白质锁定在其非活性构象而抑制RadA。

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《Biochemistry》 |2009年第29期|p.6805-6810|共6页
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Yang Li Yujiong He and Yu Luo;
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Department of Biochemistry, University of Saskatchewan, A3 Health Sciences Building, 107 Wiggins Road, Saskatoon,Saskatchewan, Canada S7N 5E5;

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1. Crystal structure of an archaeal homologue of multidrug resistance repressor protein, EmrR, from hyperthermophilic archaea Sulfolobus tokodaii strain 7. [J] . Miyazono K, Tsujimura M, Kawarabayasi Y, Proteins: Structure, Function, and Genetics . 2007,第4期

机译：嗜热古细菌Sulfolobus tokodaii菌株7的多重耐药阻遏蛋白EmrR的古细菌同源物的晶体结构。
2. Crystal structure of a ribonuclease P protein Ph1601p from Pyrococcus horikoshii OT3: An archaeal homologue of human nuclear ribonuclease P protein Rpp21 [J] . Kakuta Y, Ishimatsu I, Numata T, Biochemistry . 2005,第36期

机译：霍氏热球菌OT3的核糖核酸酶P蛋白Ph1601p的晶体结构：人核糖核酸酶P蛋白Rpp21的古菌同源物。
3. Crystal structure of archaeal RNase HII: a homologue of human major RNase H [J] . Lai LH., Hung LW., Kim R., Structure . 2000,第8期

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4. Crystal structure transformations during phase transitions in homologues of n-alkanes: C_(23)H_(48), C_(24)H_(50), C_(25)H_(52) as revealed by FT-IR spectroscopy [C] . S A Gureva, V A Marikhin, L P Myasnikova, International Conference PhysicA.SPb . 2020

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5. Crystal structure, substrate promiscuity and structure-based engineering of archaeal isopentenyl phosphate kinase [D] . Mabanglo, Mark Noel F. 2012

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6. Crystal structures of the archaeal RNase P protein Rpp38 in complex with RNA fragments containing a K-turn motif [O] . Kosuke Oshima, Xuzhu Gao, Seiichiro Hayashi, 2018

机译：古细菌RNase P蛋白Rpp38的晶体结构与包含K转基序的RNA片段复合
7. Crystal structure of archaeal RNase HII: a homologue of human major RNase H [O] . Lai Luhua, Yokota Hisao, Hung Li-Wei, 2000

机译：古细菌RNase HII的晶体结构：人类主要RNase H的同源物

Crystal Structure of an Archaeal Rad51 Homologue in Complex with a Metatungstate Inhibitor

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