Double-Strand Break Formation during Nucleotide Excision Repair of a DNA Interstrand Cross-Link

Jonathan T. Sczepanski Aaron C. Jacobs Bennett Van Houten and Marc M. Greenberg

首页> 外文期刊>Biochemistry >Double-Strand Break Formation during Nucleotide Excision Repair of a DNA Interstrand Cross-Link

【24h】

Double-Strand Break Formation during Nucleotide Excision Repair of a DNA Interstrand Cross-Link

机译：DNA链间交联的核苷酸切除修复过程中的双链断裂形成。

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

TheDNA interstrand cross-link (ICL) resultingnfrom the C40n-oxidized abasic site (C4-AP) is a uniquenclustered lesion comprised of a cross-link adjacent to annick. The ICL is a substrate for the UvrABC nucleotidenexcision repair system. The strand containing the nick isnpreferentially incised, but the nick influences the cleavagensites. Moreover, in approximately 15% of the molecules,nthe strand opposite the nick is incised, resulting in a morentoxic double-strand break. This is the first example innwhich an interstrand cross-link is converted by nucleotidenexcision misrepair into a more deleterious double-strandnbreak.

机译：由C40n氧化的无碱基位点（C4-AP）产生的DNA链间交联（ICL）是一种独特的簇集病变，由邻近于annick的交联组成。 ICL是UvrABC核苷酸切除修复系统的底物。含有缺口的链不优先切开，但缺口会影响劈裂位。此外，在大约15％的分子中，与缺口相对的链被切开，导致更具毒性的双链断裂。这是第一个通过核苷酸连接错配将链间交联转化为更有害的双链断裂的实例。

著录项

来源
《Biochemistry》 |2009年第32期|p.7565-7567|共3页
作者
Jonathan T. Sczepanski Aaron C. Jacobs Bennett Van Houten and Marc M. Greenberg;
展开▼
作者单位

‡Department of Chemistry, Johns Hopkins University, 3400 North Charles Street, Baltimore, Maryland 21218, and §Laboratory ofMolecular Genetics, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park,North Carolina 27709.) Current address: Department of Pharmacology and Chemical Biology, Hillman Cancer Center, 5117Centre Ave., Suite 2.6, Pittsburgh, PA 15213.;

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类
关键词

相似文献

外文文献
中文文献
专利

1. Nucleotide Excision Repair of a DNA Interstrand Cross-Link Produces Single- and Double-Strand Breaks [J] . Xiaohua Peng Avik K. Ghosh Bennett Van Houten and Marc M. Greenberg* Biochemistry . 2010,第1期

机译：DNA链间交联的核苷酸切除修复产生单链和双链断裂。
2. Nucleotide Excision Repair of a DNA Interstrand Cross-Link Produces Single- and Double-Strand Breaks [J] . Xiaohua Peng, Avik K. Ghosh, Bennett Van Houten, Biochemistry . 2010,第1期

机译：DNA链间交联的核苷酸切除修复产生单链和双链断裂。
3. Initiation of DNA interstrand cross-link repair in humans: the nucleotide excision repair system makes dual incisions 5' to the cross-linked base and removes a 22- to 28-nucleotide-long damage-free strand. [J] . T Bessho, D Mu, A Sancar Molecular and Cellular Biology . 1997,第12期

机译：在人类中启动DNA链间交联修复：核苷酸切除修复系统在交联碱基的5'处形成双切口，并去除了22至28个核苷酸长的无损伤链。
4. Arsenite Binds to the RING Finger Domain of FANCL E3 Ubiquitin Ligase and Inhibits DNA Interstrand Cross-link Repair [C] . Ji Jiang, Lin Li, Pengcheng Wang, ASMS Conference on Mass Spectrometry and Allied Topics . 2016

机译：亚砷酸盐与FANCL E3泛素连接酶的铃声域粘合并抑制DNA Interstrand Cross-Link修复
5. Multiple DNA binding domains mediate the function of ERCC1-XPF in nucleotide excision repair and interstrand crosslink repair. [D] . Su, Yan. 2012

机译：多个DNA结合域介导ERCC1-XPF在核苷酸切除修复和链间交联修复中的功能。
6. Double Strand Break Formation During Nucleotide Excision Repair of a DNA Interstrand Cross-link [O] . Jonathan T. Sczepanski, Aaron C. Jacobs, Bennett Van Houten, -1

机译：双链断裂形成过程中的DNa链间交联的核苷酸切除修复
7. Initiation of DNA interstrand cross-link repair in humans: the nucleotide excision repair system makes dual incisions 5' to the cross-linked base and removes a 22- to 28-nucleotide-long damage-free strand. [O] . Bessho, T, Mu, D, Sancar, A 1997

机译：在人类中启动DNA链间交联修复：核苷酸切除修复系统在交联碱基的5'处形成双切口，并去除了22至28个核苷酸长的无损伤链。

Double-Strand Break Formation during Nucleotide Excision Repair of a DNA Interstrand Cross-Link

摘要

著录项

相似文献

相关主题

期刊订阅