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首页> 外文期刊>BioChip journal >Innate immune response gene expression profiles in specific pathogen-free chickens infected with avian influenza virus subtype H9N2
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Innate immune response gene expression profiles in specific pathogen-free chickens infected with avian influenza virus subtype H9N2

机译：感染H9N2亚型禽流感的特定无病原体鸡的先天免疫应答基因表达谱

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摘要

In poultry species, H9N2 low pathogenic avian influenza (LPAI) virus infections frequently lead to low to moderate mortality rates and morbidity characterized by depression, respiratory disease symptoms, and decreases in egg production. Since current knowledge on the avian immune response to H9N2 infection is limited, we used microarray analysis to examine global changes in immune-related gene expression induced by H9N2 LPAI infection in specific pathogen-free chickens. The expression profiles of approximately 800 genes, including those that influence cell differentiation, transcription, transport, immune responses, and signal transduction, were altered by H9N2 infection. A complete chicken genome microarray analysis identified a strong innate antiviral host response after infection in spleens. In particular, a significant number of immune response genes, including interferon genes and related immune response genes, were up-regulated following H9N2 infection. The increased transcription of 2'-5'-oligoadenylate synthetase and myxovirus resistance genes was confirmed by real-time RT-PCR. These results suggest that the host response generated against H9N2 infection may contribute to protective effects by manipulating innate immune responses.
机译：在禽类中，H9N2低致病性禽流感（LPAI）病毒感染经常导致低至中等的死亡率和发病率，其特征在于抑郁，呼吸道疾病症状和产蛋量减少。由于目前对禽类对H9N2感染的免疫反应的知识有限，因此我们使用微阵列分析来检查在特定的无病原体鸡中H9N2 LPAI感染诱导的免疫相关基因表达的总体变化。 H9N2感染改变了大约800个基因的表达谱，包括那些影响细胞分化，转录，转运，免疫应答和信号转导的基因。完整的鸡基因组微阵列分析确定了脾脏感染后强烈的先天抗病毒宿主反应。特别地，在H9N2感染后，大量免疫应答基因，包括干扰素基因和相关的免疫应答基因，被上调。实时RT-PCR证实了2'-5'-寡腺苷酸合成酶和粘液病毒抗性基因的转录增加。这些结果表明，针对H9N2感染产生的宿主反应可能通过操纵先天性免疫反应而有助于保护作用。

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  • 来源
    《BioChip journal》 |2013年第4期|393-398|共6页
  • 作者

    Dong-Hun Lee; Seong-Su Yuk; Jae-Keun Park; Jung-Hoon Kwon; Tseren-Ochir Erdene-Ochir; Jin-Yong Noh; So Yeon Yu; Seung Yong Hwang; Sang-Won Lee; Chang-Seon Song;

  • 作者单位

    Avian Disease Laboratory, College of Veterinary Medicine, Konkuk University, Seoul, Korea;

    Avian Disease Laboratory, College of Veterinary Medicine, Konkuk University, Seoul, Korea;

    Avian Disease Laboratory, College of Veterinary Medicine, Konkuk University, Seoul, Korea;

    Avian Disease Laboratory, College of Veterinary Medicine, Konkuk University, Seoul, Korea;

    Avian Disease Laboratory, College of Veterinary Medicine, Konkuk University, Seoul, Korea;

    Avian Disease Laboratory, College of Veterinary Medicine, Konkuk University, Seoul, Korea;

    Department of Biochemistry, Hanyang University, Sangrok-gu, Ansan, Gyeonggi-do 426-791, Korea,GenoCheck Co. Ltd., Guro-gu, Seoul 152-766, Korea;

    Department of Biochemistry, Hanyang University, Sangrok-gu, Ansan, Gyeonggi-do 426-791, Korea,GenoCheck Co. Ltd., Guro-gu, Seoul 152-766, Korea;

    Avian Disease Laboratory, College of Veterinary Medicine, Konkuk University, Seoul, Korea;

    Avian Disease Laboratory, College of Veterinary Medicine, Konkuk University, Seoul, Korea;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Avian influenza virus; H9N2; Microarray; Innate immunity; Interferon;

    机译：禽流感病毒;H9N2;微阵列;先天免疫;干扰素;

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