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Ultrasound-stimulated drug release from polymer micro and nanoparticles

机译:超声刺激聚合物微颗粒和纳米颗粒释放药物

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摘要

Ultrasound-responsive drug delivery systems have great potential for applications requiring stimulated release in vivo with a high degree of control over spatial and temporal location. In this study, systematic investigations were carried out to determine the effect of various ultrasound exposure parameters, in particular, output power, duty cycle and exposure time, on the release rate of a model drug (estradiol), encapsulated in poly DL-lactide-co-glycolide particles of different sizes prepared using electrohydrodynamic processing. The effect of ultrasound exposure on the degradation and surface morphology of the particles was also studied through optical and electron microscopy. There was found to be a positive correlation between drug release and each of the ultrasound parameters investigated, with output power having the most significant effect on both release rate and the morphology of the particles. The increase in surface porosity observed indicates that degradation may be attributed to cavitation phenomena.
机译:超声响应药物递送系统对于需要体内刺激释放并高度控制空间和时间位置的应用具有巨大潜力。在这项研究中,我们进行了系统的调查,以确定各种超声暴露参数(尤其是输出功率,占空比和暴露时间)对封装在聚DL-丙交酯-中的模型药物(雌二醇)释放速率的影响。使用电动流体力学方法制备的不同尺寸的共乙交酯颗粒。还通过光学和电子显微镜研究了超声暴露对颗粒降解和表面形态的影响。发现药物释放与研究的每个超声参数之间存在正相关,输出功率对释放速率和颗粒形态均具有最显着的影响。观察到的表面孔隙率增加表明降解可能归因于空化现象。

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