• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Bioinspired, biomimetic and nanobiomaterials >The protein corona effect for targeted drug delivery
【24h】

The protein corona effect for targeted drug delivery

机译：蛋白质电晕效应用于靶向药物递送

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

At present, ligand binding to nanoparticle surface is the most widespread strategy for targeting specific tissues by a receptormediated mechanism. However, the nanoparticles are immediately covered by a protein-rich layer when administrated in vivo, the so-called "protein corona", with the immediate consequence that the ligand-receptor recognition may be obscured. It is not the nanoparticle-bulk composition or surface functionalization but rather the identity, arrangement and residence time of the proteins of the corona that determine the nanoparticle bioidentity, and this is an emerging concept available for use to target specific cell types in a controlled manner. An in-depth understanding of the relationship between surface properties of nanoparticles and composition of the "protein corona" is a fundamental step toward the design of nanoparticles that, once in the blood, become covered by specific proteins able to deliver them at the right site of action and promote efficient cell internalization. This "protein corona effect" is a formidable challenge that could lead to a complete renewal of the current strategies of targeted drug delivery.
机译：目前，配体与纳米颗粒表面的结合是通过受体介导的机制靶向特定组织的最广泛策略。然而，当在体内施用时，纳米颗粒立即被富含蛋白质的层覆盖，即所谓的“蛋白质电晕”，其直接结果是可能使配体-受体识别模糊。决定纳米粒子生物特性的不是纳米粒子的整体组成或表面功能化，而是电晕蛋白质的身份，排列和停留时间，这是一个新兴概念，可用于以受控方式靶向特定细胞类型。深入了解纳米粒子的表面性质与“蛋白质电晕”的组成之间的关系是纳米粒子设计的基本步骤，该纳米粒子一旦进入血液，就会被能够在正确部位递送的特定蛋白质覆盖作用并促进有效的细胞内在化。这种“蛋白质电晕效应”是一个巨大的挑战，可能导致对靶向药物递送的当前策略的彻底更新。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号