...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Biological Trace Element Research >Effect of selenite treatment on ultrastructural changes in experimental diabetic rat bones
【24h】

Effect of selenite treatment on ultrastructural changes in experimental diabetic rat bones

机译：亚硒酸盐对实验性糖尿病大鼠骨骼超微结构变化的影响

获取原文
获取原文并翻译 | 示例
   

获取外文期刊封面封底 >>

       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

It is known that streptozotocin (STZ)-induced diabetes causes functional and structural alterations in some types of tissue and organ. A number of methods have been used to characterize the properties of diabetic tissues and their diagnosis. Selenium compounds, playing an antioxidant role, can restore some altered metabolic parameters and diminished functions in experimental diabetes. The first aim of the present study was to investigate the effects of STZ-induced diabetes on structural properties of rat long bones. Electron and light microscopic observations showed deleterious alterations in the structure of the diabetic rat long bones, the most prominent effect being in osteocytic cells. Fine cytoplasmic processes of the osteocytes seemed to be shortened, and diabetes affected the normal cytoplasmic processes in a negative manner. The second aim of the present study was to evaluate the effects of sodium selenite treatment for 4 wk on the long bones of the diabetic rats. Electron and light microscopic observations demonstrated that sodium selenite treatment prevented the STZ-induced structural as well as ultrastructural changes in the long bones of the rats. In conclusion, this study first showed that a period of 5-wk diabetes was enough to cause some important and degenerative changes in the structure of the bone tissues, and, second, it demonstrated that sodium selenite treatment of the diabetic rats could normalize these alterations.
机译：已知链脲佐菌素（STZ）诱导的糖尿病会导致某些类型的组织和器官功能和结构改变。已经使用许多方法来表征糖尿病组织的特性及其诊断。硒化合物起着抗氧化剂的作用，可以恢复实验性糖尿病中某些代谢参数的改变和功能的减弱。本研究的首要目的是研究STZ诱导的糖尿病对大鼠长骨结构特性的影响。电子和光学显微镜观察显示，糖尿病大鼠长骨的结构发生了有害的变化，最明显的影响是在骨细胞中。骨细胞的精细细胞质过程似乎缩短了，而糖尿病以负面的方式影响了正常细胞质过程。本研究的第二个目的是评估亚硒酸钠治疗4周对糖尿病大鼠长骨的影响。电子和光学显微镜观察表明，亚硒酸钠处理可防止STZ诱导的大鼠长骨结构和超微结构变化。总之，这项研究首先表明，一个5周的糖尿病期足以引起骨骼组织结构发生一些重要的退化性变化，其次，它表明对糖尿病大鼠的亚硒酸钠治疗可以使这些改变正常化。 。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号