Electrical activity and circulatory effects of nitrite in the rat cerebrum

Shumilova T. E.; Smirnov A. G.; Shereshkov V. I.; Fedorova M. A.; Nozdrachev A. D.

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Electrical activity and circulatory effects of nitrite in the rat cerebrum

机译：大鼠大脑中亚硝酸盐的电活动和循环作用

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An association between the cerebrum electrical activity (CEA) in rats, blood supply of its cortex microregions (linear blood flow), and general cerebrum blood flow under acute nitrite hypoxia was studied. The phase character of the change in hemodynamic indices and the total capacity of electroencephalography (EEG) spectrum for 75 min after sodium nitrite introduction (30 mg/kg of body weight) was detected. The first phase (30 min) was associated with cerebrum adaptation to hypotension caused by nitrite and was completed by EEG normalization. The second phase was characterized by pathological EEG changes (in spite of restoration of hemodynamics in the cerebrum) caused by the growth of oxygen debt in the nervous tissue as a result of a decrease in the blood oxygen capacity by 60-75 min of the effect of nitrite.

机译：研究了大鼠的脑电活动（CEA），其皮质微区的血液供应（线性血流）与急性亚硝酸盐低氧条件下的一般脑血流之间的关系。检测亚硝酸钠引入（75 mg / kg体重）后75分钟的血流动力学指标变化的相位特征和脑电图（EEG）谱的总容量。第一阶段（30分钟）与大脑适应亚硝酸盐引起的低血压有关，并通过EEG正常化完成。第二阶段的特征是病理性脑电图变化（尽管大脑血流动力学得以恢复），这是由于血液中氧含量降低60-75分钟而导致的神经组织中氧含量增加导致的亚硝酸盐。

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《Biology Bulletin》 |2015年第2期|139-144|共6页
作者
Shumilova T. E.; Smirnov A. G.; Shereshkov V. I.; Fedorova M. A.; Nozdrachev A. D.;
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St Petersburg State Univ, St Petersburg 199034, Russia;

St Petersburg State Univ, St Petersburg 199034, Russia;

St Petersburg State Univ, St Petersburg 199034, Russia;

Univ Leipzig, Inst Bioanalyt Chem, Ctr Biotechnol & Biomed, D-04103 Leipzig, Germany;

St Petersburg State Univ, St Petersburg 199034, Russia;

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Electrical activity and circulatory effects of nitrite in the rat cerebrum

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