Intracellular Transmission of the Cholinergic Signal in the Chick Amnion

O. V. Boiko; B. N. Manukhin

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Intracellular Transmission of the Cholinergic Signal in the Chick Amnion

机译：小鸡羊膜中胆碱能信号的细胞内传递。

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The role of the system of deposited calcium in the mediation of contractile reactions to carbachol in an isolated amnion of 11-13 day old chicken embryo was studied. It was found that thapsigargin (2 μM, 20 min), an inhibitor of the endoplasmic reticulum Ca~(2+)-ATPases, decreases the tonic reaction to carbachol by 40 + 2%. In the presence of U73122 (5-10 μM, 10 min), a phosphoinositide-specific phospholipase C inhibitor, the rhythmic contractile reaction of the amnion to carbachol is blocked, whereas the tonic reaction decreases to 47 ± 9% of the initial one. Ryanodine (10 μM, 5 min) inhibits the spontaneous contractile activity of the amnion and decreases the tonic reaction to carbachol to 36 ± 3% relative to control. In the presense of ryanodine, nifedipine (0.05 μM) completely blocks the tonic reaction to carbachol. Thus, calcium mobilized from intracellular stores via inositol trisphosphate and ryanodine receptors is involved in realization of contractile reactions, mediated by M3 receptors, in the chick amnion.

机译：研究了沉积钙系统在介导的11-13日龄鸡胚羊膜中对卡巴胆碱的收缩反应的介导作用。已发现thapsigargin（2μM，20分钟）是内质网Ca〜（2 +）-ATPase的抑制剂，可使对卡巴胆碱的强直反应降低40 + 2％。在U73122（5-10μM，10分钟）的存在下，一种磷酸肌醇特异性磷脂酶C抑制剂可阻止羊膜对卡巴胆碱的节律性收缩反应，而强直反应减少至最初的47±9％。 Ryanodine（10μM，5分钟）抑制羊膜的自发收缩活性，并使对卡巴胆碱的强直反应相对于对照组降低至36±3％。在瑞丹定的存在下，硝苯地平（0.05μM）完全阻断了对卡巴胆碱的强直反应。因此，通过肌醇三磷酸肌醇和ryanodine受体从细胞内储存物中调动的钙参与了由雏鸡羊膜中M3受体介导的收缩反应的实现。

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《Biology Bulletin》 |2014年第1期|55-59|共5页
作者
O. V. Boiko; B. N. Manukhin;
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Kol'tsov Institute of Developmental Biology, Russian Academy of Sciences, ul. Vavilova 26, Moscow, 119334 Russia;

Kol'tsov Institute of Developmental Biology, Russian Academy of Sciences, ul. Vavilova 26, Moscow, 119334 Russia;

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Intracellular Transmission of the Cholinergic Signal in the Chick Amnion

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