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首页> 外文期刊>Biology Bulletin >Bioaccumulation of Silver and Gold Nanoparticles in Organs and Tissues of Rats Studied by Neutron Activation Analysis
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Bioaccumulation of Silver and Gold Nanoparticles in Organs and Tissues of Rats Studied by Neutron Activation Analysis

机译：中子活化分析研究银和金纳米颗粒在大鼠器官和组织中的生物富集

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摘要

Bioaccumulation of silver (Ag) and gold (Au) nanoparticles (NPs) with mean sizes of 35 run and 6 nm, respectively, has been studied after their intragastric administration to rats at a dose of 100 μg/kg of body weight for 28 or 14 days. The organs and tissues (liver, kidney, spleen, heart, gonads, brain, and blood) were subjected to thermal neutron activation, and, then, the activity of the ~(110m)Ag and ~(198)Au isotopes generated was measured. The NPs of both metals were detected in all biological samples studied, the highest specific weight and content of Ag NP being found in the liver, and those of Au being found in kidneys of animals. The content of Ag NPs detected in the brain was 66.4 + 5.6 ng (36 ng/g tissue), no more than 7% of these NPs being localized in the lumen of brain blood vessels. The content of Ag and Au NPs found in organs and tissues of rats could be regarded as nonhazardous (nontoxic) in accordance with the known literature data.
机译：在分别以100μg/ kg体重的剂量向大鼠胃内给药28或30毫克后，分别研究了平均粒径分别为35 nm和6 nm的银（Ag）和金（Au）纳米颗粒（NPs）的生物蓄积性。 14天对器官和组织（肝脏，肾脏，脾脏，心脏，性腺，大脑和血液）进行热中子活化，然后测量〜（110m）Ag和〜（198）Au同位素的活性。在所有研究的生物样品中都检测到了这两种金属的NP，在肝脏中发现了最高的比重和含量的Ag NP，在动物肾脏中发现了Au的比重和含量。在大脑中检测到的Ag NP含量为66.4 + 5.6 ng（36 ng / g组织），其中不超过7％的这些NP定位在脑血管腔中。根据已知的文献数据，在大鼠的器官和组织中发现的Ag和Au NPs的含量可以被认为是无害的（无毒的）。

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  • 来源
    《Biology Bulletin》 |2014年第3期|255-263|共9页
  • 作者

    Yu. P. Buzulukov; E. A. Arianova; V. F. Demin; I. V. Safenkova; I. V. Gmoshinski; V. A. Tutelyan;

  • 作者单位

    National Research Center Kurchatov Institute, pl. Kurchatova 1, Moscow, 123182 Russia;

    Institute of Nutrition, Russian Academy of Medical Sciences, Ust'inskii proezd 2/14, Moscow, 109240 Russia;

    National Research Center Kurchatov Institute, pl. Kurchatova 1, Moscow, 123182 Russia;

    Bakh Institute of Biochemistry, Russian Academy of Science, Leninskii pr. 33/2, Moscow, 119071 Russia;

    Institute of Nutrition, Russian Academy of Medical Sciences, Ust'inskii proezd 2/14, Moscow, 109240 Russia;

    National Research Center Kurchatov Institute, pl. Kurchatova 1, Moscow, 123182 Russia;

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