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首页> 外文期刊>Biology Bulletin >Correlation of Renal Solute-Free Water Reabsorption and Energy of Interaction of Vasotocin Analogs With V2 Receptor
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Correlation of Renal Solute-Free Water Reabsorption and Energy of Interaction of Vasotocin Analogs With V2 Receptor

机译：肾无溶质水重吸收与血管紧张素类似物与V2受体相互作用的能量的相关性

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摘要

The nonapeptide-receptor interaction energy calculated from docking algorithms was compared with the effect of the same peptides upon solute-free water reabsorption in rat kidney in vivo. Vasotocin and some of its analogs were injected intramuscularly into conscious female Wistar rats in doses from 0.1 pmol to 0.5 nmol/kg of body weight after oral water load (50 ml/kg of body weight). A significant correlation was found between the calculated energy of peptide interaction with V2 receptors and an increase in the renal solute-free water reabsorption stimulated by injection of nonapeptides. The results evidence that physiological changes in rat kidney in vivo induced by vasotocin analogs can be accurately simulated by virtual modeling of their interactions with V2 receptors.
机译：将通过对接算法计算出的非肽-受体相互作用能与相同肽对大鼠肾脏体内无溶质水重吸收的影响进行了比较。在口服水负荷（50 ml / kg体重）后，以0.1 pmol至0.5 nmol / kg体重的剂量将Vasotocin及其某些类似物肌内注射到清醒的雌性Wistar大鼠中。发现肽与V2受体相互作用的能量与注射非肽刺激的无肾溶质水重吸收增加之间存在显着相关性。结果表明，通过血管生成素类似物与V2受体相互作用的虚拟模型，可以准确模拟血管生成素在大鼠肾脏中的生理变化。

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  • 来源
    《Biology Bulletin》 |2011年第6期|p.615-621|共7页
  • 作者

    A. V. Kutina; T. A. Karavashkina; E. I. Shakhmatova; J. Gao; D. Yu. Mordvintsev; D. A. Kuzmin; V. I. Tsetlin; Yu. V. Natochin;

  • 作者单位

    Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences,prosp. M. Toreza 44, St. Peterburg, 194223 Russia;

    Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences,prosp. M. Toreza 44, St. Peterburg, 194223 Russia;

    Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences,prosp. M. Toreza 44, St. Peterburg, 194223 Russia;

    Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences,prosp. M. Toreza 44, St. Peterburg, 194223 Russia;

    Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences,ul. Miklukho-Maklaya 16/10, Moscow, 117997 Russia;

    Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences,ul. Miklukho-Maklaya 16/10, Moscow, 117997 Russia;

    Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences,ul. Miklukho-Maklaya 16/10, Moscow, 117997 Russia;

    Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences,prosp. M. Toreza 44, St. Peterburg, 194223 Russia;

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