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Influence of Semax on the Emotional State of White Rats in the Norm and Against the Background of Cholecystokinin-Tetrapeptide Action

机译：Semax对正常大鼠和胆囊收缩素-四肽作用背景下白鼠情绪状态的影响

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摘要

The effects of the adrenocorticotropic hormone (ACTH(4-10)) analog, Semax (MEHFPGP), on the level of anxiety and depression in white rats have been studied in the normal state and against the background of cholecystokinin-tetrapeptide (CCK-4) action. Semax was injected intranasally in doses of 50 and 500 μg/kg 15 min before the testing. CCK-4 was administered intraperitoneally in a dose of 400 μg/kg 40 min before the testing. The level of anxiety was estimated in the elevated plus-maze test, and the degree of depression, in the forced swimming test. Semax administration did not influence the emotional state of animals in the normal state. The CCK-4 injection led to an increase in anxiety and depression in rats. Semax normalized the animal behavior disturbed by the CCK-4 administration, which attests to its anxiolytic and antidepressant effects at elevated levels of anxiety and depression.
机译：在正常状态和胆囊收缩素四肽（CCK-4）背景下，研究了促肾上腺皮质激素（ACTH（4-10））类似物Semax（MEHFPGP）对白色大鼠焦虑和抑郁水平的影响）动作。在测试前15分钟，以50和500μg/ kg的剂量鼻内注射Semax。在测试前40分钟以400μg/ kg的剂量腹膜内施用CCK-4。在高迷迷宫测试中评估了焦虑水平，在强迫游泳测试中评估了抑郁程度。 Semax给药不会影响正常状态下动物的情绪状态。 CCK-4注射导致大鼠焦虑和抑郁增加。 Semax使受CCK-4给药干扰的动物行为正常化，这证明了其在焦虑和抑郁水平升高时的抗焦虑和抗抑郁作用。

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  • 来源
    《Biology Bulletin》 |2010年第2期|p.186-192|共7页
  • 作者

    N. G. Levitskaya; D. A. Vilenskii; E. A. Sebentsova; L. A. Andreeva; A. A. Kamensky; N. F. Myasoedov;

  • 作者单位

    Institute of Molecular Genetics, Russian Academy of Sciences, Moscow;

    rnFaculty of Biology, Moscow State University, Moscow;

    rnInstitute of Molecular Genetics, Russian Academy of Sciences, Moscow;

    Institute of Molecular Genetics, Russian Academy of Sciences, Moscow;

    rnFaculty of Biology, Moscow State University, Moscow;

    rnInstitute of Molecular Genetics, Russian Academy of Sciences, Moscow;

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