Asymmetric Cell Division and Neoplastic Growth

V. V. Teskikh; A. V. Vasilev; E. A. Vorotelyak

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Asymmetric Cell Division and Neoplastic Growth

机译：不对称细胞分裂和肿瘤生长

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Asymmetric division was formed as an evolutionary conserved mechanism of self-maintenance of cellular populations and creation of a variety of cell types during ontogenesis. Asymmetric division enables a special mechanism of determinant segregation, which further defines development of daughter cells. As a result two unequal cells are developed. Recent research demonstrates the interplay of disturbed asymmetric division of stem cells and tumorigenesis. Genes implicated in cell's polarization and normal progression of asymmetric mitosis were identified in Drosophila. Other genes regulating asymmetric mitosis were described as tumor suppressors, and their mutations were shown to initiate neoplastic growth. Comparative study of gene expression suggests that the disturbance of asymmetric division might be one of the reasons for neoplasm progression in vertebrates.

机译：不对称分裂的形成是细胞群体自我维持和在本体形成过程中创建各种细胞类型的进化保守机制。不对称分裂使行列式分离的特殊机制成为可能，它进一步定义了子代细胞的发育。结果，发展出两个不相等的细胞。最近的研究表明干细胞不对称分裂与肿瘤发生的相互作用。果蝇中鉴定出与细胞的极化和不对称有丝分裂的正常进程有关的基因。其他调节不对称有丝分裂的基因被描述为肿瘤抑制因子，并且它们的突变被证明可引发肿瘤生长。基因表达的比较研究表明，不对称分裂的干扰可能是脊椎动物肿瘤进展的原因之一。

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《Biology Bulletin》 |2009年第4期|323-327|共5页
作者
V. V. Teskikh; A. V. Vasilev; E. A. Vorotelyak;
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Institute of Developmental Biology, Russian Academy of Sciences, ul. Vavilova, 26, Moscow, 119334 Russia;

Institute of Developmental Biology, Russian Academy of Sciences, ul. Vavilova, 26, Moscow, 119334 Russia;

Institute of Developmental Biology, Russian Academy of Sciences, ul. Vavilova, 26, Moscow, 119334 Russia;

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1. CEH-20/Pbx and UNC-62/Meis function upstream of rnt-1/Runx to regulate asymmetric divisions of the C. elegans stem-like seam cells CEH-20/Pbx and UNC-62/Meis function upstream of rnt-1/Runx to regulate asymmetric divisions of the C. elegans stem-like seam cells CEH-20/Pbx and UNC-62/Meis function upstream of rnt-1/Runx to regulate asymmetric divisions of the C. elegans stem-like seam cells [J] . Peter J. Appleford, Samantha Hughes, Charles Brabin, Biology Open . 2013,第7期

机译：CEH-20 / Pbx和UNC-62 / Meis在rnt-1 / Runx的上游起作用，以调节线虫茎状接缝细胞的不对称分裂CEH-20 / Pbx和UNC-62 / Meis在rnt-1的上游发挥作用/ Runx调节线虫干样接缝细胞的不对称分裂CEH-20 / Pbx和UNC-62 / Meis在rnt-1 / Runx的上游起作用以调节线虫干样接缝细胞的不对称分裂
2. Asymmetric cell division of granule neuron progenitors in the external granule layer of the mouse cerebellum Asymmetric cell division of granule neuron progenitors in the external granule layer of the mouse cerebellum Asymmetric cell division of granule neuron progenitors in the external granule layer of the mouse cerebellum [J] . Shyamala Mani, Parthiv Haldipur, Vinod Periasamy, Biology Open . 2015,第7期

机译：小鼠小脑外部颗粒层中颗粒神经元祖细胞的不对称细胞分裂小鼠小脑外部颗粒层中颗粒神经元祖细胞的不对称细胞分裂小鼠小脑外部颗粒层中颗粒神经元祖细胞的不对称细胞分裂
3. Exact solution of the functional Fokker-Planck equation for cell growth with asymmetric cell division [J] . Lo C. F. Physica, A. Statistical mechanics and its applications . 2019,第期

机译：用非对称细胞分裂函数Fokker-Planck方程的精确解
4. Re-examination of the significance of nuclear localization of PLCP1 in the likelihood of itsinvolvement in neoplastic cell growth [C] . Lucio Cocco, Lucia Manzoli, Ottavio Barnabei, International Symposium on Regulation of Enzyme Activity and Synthesis in Normal and Neoplastic Tissues . 2003

机译：重新审查PLCP1核定位在肿瘤细胞生长中的核定位的重要性
5. A study of human homologs of selected Drosophila genes in human mammary ductal carcinoma, asymmetric cell division of human neural stem cells and a multiplex microsphere bead assay for comparative RNA expression analysis. [D] . Fuja, Tannin J. 2003

机译：对人类乳腺导管癌中所选果蝇基因的人类同源物，人类神经干细胞的不对称细胞分裂以及用于比较RNA表达分析的多重微球珠分析的研究。
6. CBIO-30DISRUPTED OLIGODENDROCYTE PRECURSOR CELL ASYMMETRIC DIVISION GENERATES PHENOTYPES REMINISCENT OF NEOPLASTIC TRANSFORMATION [O] . Ian Meyers, Hannah Collins, Banafsheh Kadhkodaei, 2015

机译：CBIO-30破坏的少突胶质细胞前体细胞的不对称分裂产生表型使肿瘤转化
7. STEM-14. GROWTH FACTOR RECEPTOR CO-INHERITANCE DURING ASYMMETRIC CELL DIVISION DRIVES THE CANCER STEM CELL PHENOTYPE [O] . Masahiro Hitomi, Anastasia Chumakova, Stephanie Jarvis, 2018

机译：Stew-14。不对称细胞分裂期间的生长因子受体共遗传驱动癌症干细胞表型
8. Mechanism of Integrim-Mediated Growth Control in Normal, Transformed, and Neoplastic Breast Cells [R] . Wayner, E. , Tamura, R. 1999

机译：整合素介导的正常，转化和肿瘤乳腺细胞生长控制的机制

Asymmetric Cell Division and Neoplastic Growth

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