Some Mechanisms of the Direct and Indirect Effects of Chorionic Gonadotropin on the Phagocytic Activity of Leukocytes

S. V. Shirshev; O. L. Gorbunova

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Some Mechanisms of the Direct and Indirect Effects of Chorionic Gonadotropin on the Phagocytic Activity of Leukocytes

机译：绒毛膜促性腺激素对白细胞吞噬活性的直接和间接作用的一些机制

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The effects of chorionic gonadotropin (CG) and CG-induced hormonal background on the phagocytic activity of peripheral blood leukocytes and peritoneal macrophages were studied in female Swiss mice. In vitro, the direct immunosuppressing effect of CG on phagocytes depended on the function of L-type Ca~(2+) channels and was increased by an additional paracrine regulation by prostaglandins. At the systemic level, the CG effects depended on the activated production of sex steroids, which abolished the phagocyte-suppressing effect of CG and the development of adaptive immune responses.

机译：在雌性瑞士小鼠中研究了绒毛膜促性腺激素（CG）和CG诱导的激素背景对外周血白细胞和腹膜巨噬细胞吞噬活性的影响。在体外，CG对吞噬细胞的直接免疫抑制作用取决于L型Ca〜（2+）通道的功能，并通过前列腺素的额外旁分泌调节而增加。在系统水平上，CG作用取决于性类固醇的激活产生，从而消除了CG的吞噬细胞抑制作用和适应性免疫应答的发展。

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《Biology Bulletin》 |2008年第1期|p.17-21|共5页
作者
S. V. Shirshev; O. L. Gorbunova;
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Institute of Ecology and Genetics of Microorganisms, Russian Academy of Sciences, ul. Goleva 13, Perm, 614081 Russia;

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正文语种 eng
中图分类生物科学;
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Some Mechanisms of the Direct and Indirect Effects of Chorionic Gonadotropin on the Phagocytic Activity of Leukocytes

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