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Effect of Thymopentin on the Production of Cytokines, Heat Shock Proteins, and NF-κB Signaling Proteins

机译：胸腺五肽对细胞因子，热休克蛋白和NF-κB信号传导蛋白产生的影响

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摘要

In vivo effects of thymopentin, an active fragment of the naturally occurring thymic hormone thy-mopoietin, on the production of cytokines, nitric oxide, heat shock proteins, and signaling proteins NF-κB, phNF-κB, and IκB-α in lymphoid cells of male NMRI mice was studied. Activation of production of several cytokines (IL-1α, IL-2, IL-6, IL-10, and IFN-γ), nitric oxide, and heat shock proteins (HSP70 and HSP90) was observed in peritoneal macrophages and spleen lymphocytes of mice that received intraperitoneal injections of thymopentin (15μg per 100 g body weight). Thymopentin apparently produces stress-like rather than damaging effects. A probable action mechanism of this hormone is activation of the NF-κB signaling pathway, which is most pronounced at the NF-κB phosphorylation stage.
机译：天然胸腺激素胸腺生成素的活性片段胸腺五肽对淋巴样细胞中细胞因子，一氧化氮，热休克蛋白和信号蛋白NF-κB，phNF-κB和IκB-α的产生的体内作用对雄性NMRI小鼠进行了研究。在腹膜巨噬细胞和脾脏淋巴细胞中观察到几种细胞因子（IL-1α，IL-2，IL-6，IL-10和IFN-γ），一氧化氮和热休克蛋白（HSP70和HSP90）的产生被激活。小鼠接受腹膜内注射胸腺喷丁素（每100克体重15克）。胸腺五肽显然产生类似压力的作用而不是破坏作用。这种激素的可能作用机制是激活NF-κB信号通路，这在NF-κB磷酸化阶段最为明显。

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