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首页> 外文期刊>Biology Bulletin >The Role of Visceral Receptors in the Mechanisms of Neuroimmune Interactions in Mammalian Small Intestine
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The Role of Visceral Receptors in the Mechanisms of Neuroimmune Interactions in Mammalian Small Intestine

机译：内脏受体在哺乳动物小肠神经免疫相互作用机制中的作用。

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Exogenous administration of mast cell degranulation products into blood as well as their endogenous release induced by compound 48/80 or repeated egg albumin administration to sensitized rats proved to increase activity of mesenteric afferent nerve fibers in the small intestine. In addition, the primary contact with a foreign protein triggered a cascade of chemical processes mobilizing antioxidant systems and increasing nitric oxide production in the small intestinal tissues. Interleukin-1β or Escherichia coli lipopolysaccharide injections also had a long-term stimulating effect on intestinal receptors. Indometacin inhibited the effects induced by the bacterial endotoxin and interleukin-1β. The obtained data suggest that small intestinal interoceptors can monitor chemical environment and modulate body's responses to foreign antigens. Interleukins-1β acts as a signal transmitter between immune cells and interoceptors, which is mediated by the production of secondary signal substances, in particular, prostaglandin E2 and histamine.
机译：肥大细胞脱粒产物向血液中的外源给药，以及化合物48/80诱导的内源性释放或对致敏大鼠的卵白蛋白反复给药，均证明可增加小肠肠系膜传入神经纤维的活性。此外，与外源蛋白质的主要接触引发了一系列化学过程，从而激活了抗氧化剂系统并增加了小肠组织中一氧化氮的产生。白介素-1β或大肠杆菌脂多糖注射液也对肠受体具有长期刺激作用。吲哚美辛抑制细菌内毒素和白介素-1β诱导的作用。获得的数据表明，小肠间感受器可以监测化学环境并调节人体对外源抗原的反应。白介素-1β充当免疫细胞和受体之间的信号传递者，它是由次级信号物质（尤其是前列腺素E2和组胺）的产生介导的。

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