Analysis of 15-Lipoxygenase Activity in Irradiated Thymocytes

O. E. Grichenko; A. S. Pushin; V. V. Shaposhnikova; M. Kh. Levitman; Yu. N. Korystov

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Analysis of 15-Lipoxygenase Activity in Irradiated Thymocytes

机译：辐射胸腺细胞中15-脂氧合酶活性的分析

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We studied the effect of γ-irradiation on 15-lipoxygenase activity in rat thymocytes. The enzyme activity was determined as the rate of linoleic acid oxidation by the protein fraction isolated from the control and irradiated thymocytes under standard conditions. We demonstrate lipoxygenase activation immediately after irradiation of thymocytes. High lipoxygenase activity is observed in the cells for no more than an hour after irradiation. No high lipoxygenase activity later indicates that its synthesis is not directly induced by irradiation. Irradiation-induced generation of lipid peroxides can be the factor of lipoxygenase activation.

机译：我们研究了γ辐射对大鼠胸腺细胞中15-脂氧合酶活性的影响。在标准条件下，从对照和照射的胸腺细胞中分离出的蛋白质部分，将酶活性确定为亚油酸氧化的速率。我们证明胸腺细胞照射后立即脂氧合酶激活。辐照后不超过一个小时，在细胞中观察到高脂氧化酶活性。后来没有高脂氧合酶活性表明它的合成没有被辐射直接诱导。辐射诱导的脂质过氧化物的产生可能是脂氧合酶活化的因素。

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《Biology Bulletin》 |2004年第5期|p.423-427|共5页
作者
O. E. Grichenko; A. S. Pushin; V. V. Shaposhnikova; M. Kh. Levitman; Yu. N. Korystov;
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Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Moscow oblast', 142290 Russia;

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正文语种 eng
中图分类生物科学;
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2. PURINE METABOLISM ENZYMES ACTIVITY IN FIAT'S THYMOCYTES AFTER IRRADIATION AHD AFTER THE RIBOXINE INJECTION [J] . N. G. Kudina, T. R. Andriychuk, B. O. Tsudzevich Украинский биохимический журнал: Науч.-теорет. журн. . 2003,第2期

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Analysis of 15-Lipoxygenase Activity in Irradiated Thymocytes

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