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首页> 外文期刊>Biology Bulletin >Yersinia pseudotuberculosis Thermostable Toxin Dysregulates the Functional Activity of Two Types of Phagocytes in the Holothurian Eupentacta fraudatrix
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Yersinia pseudotuberculosis Thermostable Toxin Dysregulates the Functional Activity of Two Types of Phagocytes in the Holothurian Eupentacta fraudatrix

机译：yersinia pseudotuberculosis热稳定毒素厌氧抑制了水中Eupentacta Fraudatrix两种吞噬细胞的功能活性

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摘要

The effect of a thermostable toxin of Yersinia pseudotuberculosis (in comparison with that of dexamethasone) on the functional activities of two types of phagocytes (P1 and P2) was studied in the holothurian Eupentacta fraudatrix. A high level of NO was shown to be a marker of intact P1 cells, while the high activity of arginase was a marker of P2 cells. The antioxidant defense in the P1 type was more pronounced than that of the P2 type. At the same time, the toxin inhibited the functional activity (generation of reactive oxygen species) of P1 phagocytes after 1 h of incubation and induced primarily the activity of P2 phagocytes, compared to that of P1 cells, after 24 h. In contrast to dexamethasone, which induced the transformation of the P1 phenotype into the P2 phenotype, the toxin promoted the mutual acquisition of the phenotype features by these two types of phagocytes. An analogy between the P1 and P2 phagocytes of the holothurian and M1 and M2 macrophages is discussed.
机译：在Holothurian Eupentacta Fraudatrix中研究了yersinia假偶霉素（与地塞米松的那种）对两种吞噬细胞（p1和p2）的功能活性的效果。高水平的NO被显示为完整P1细胞的标志物，而氨基酶的高活性是P2细胞的标记。 P1型的抗氧化防御比P2型更明显。同时，毒素在孵育1小时后抑制P1吞噬细胞的功能活性（反应性氧物质的产生），并且主要诱导P2吞噬细胞的活性，与P1细胞相比，24小时后。与地塞米松相比，该诱导P1表型转化为P2表型，毒素促进了这两种类型的吞噬细胞的相互捕获特征。讨论了HOLOCHURIAN和M1和M2巨噬细胞的P1和P2吞噬细胞之间的类比。

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    《Biology Bulletin》 |2019年第2期|117-127|共11页
  • 作者

    Dolmatova L. S.; Ulanova O. A.; Timchenko N. F.;

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    Russian Acad Sci Ilyichev Pacific Inst Oceanog Far East Branch Vladivostok 690041 Russia;

    Russian Acad Sci Ilyichev Pacific Inst Oceanog Far East Branch Vladivostok 690041 Russia;

    Somov Inst Epidemiol & Microbiol Vladivostok 690087 Russia;

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