Establishment of the Axial Polarity and Cell Fate in Metazoa via Canonical Wnt Signaling: New Insights from Sponges and Annelids

Kozin V. V.; Borisenko I. E.; Kostyuchenko R. P.

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Establishment of the Axial Polarity and Cell Fate in Metazoa via Canonical Wnt Signaling: New Insights from Sponges and Annelids

机译：通过Canonical WNT信号传导在Metazoa中建立轴向极性和细胞命运：海绵和环节的新见解

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In this paper, the role of the Wnt/-catenin pathway in the establishment of the body plan in multicellular animals has been analyzed. We demonstrated that at different stages of development the Wnt signaling cascade is involved in several directly unrelated processes such as inner germ layer specification, anterior-posterior axis patterning, and terminal growth. Bioinformatics analysis revealed the independent divergence of Wnt ligands in basal Metazoa and conservation of Wnt subfamilies within the Cnidaria + Bilateria clade. Polarized expression of Wnt ligands in sponge and annelid larvae has been shown, thus confirming the applicability of the existing model of the main body axis patterning to two more taxa. The -catenin localization and inhibitory analysis have provided evidence of the unlikely role for Wnt pathway in endomesoderm determination in nereid polychaetes. The evolutionary trend to establish alternative mechanisms even for key events such as segregation of germ layers has been observed in the case of more determinative ontogeny and predominance of autonomous specification, as exemplified by the heteroquadrant (unequal) type of spiral development.

机译：在本文中，分析了Wnt / -catenin途径在多细胞动物中体育计划中的作用。我们证明，在不同的发展阶段，WNT信号级联涉及几种直接无关的过程，例如内部种系规范，前后轴图案化和终端生长。生物信息学分析揭示了基础美唑的WNT配体的独立分歧和CNIDaria + Bilateria Clade中的Wnt亚属植物的保护。已经示出了海绵和环形幼虫的Wnt配体的偏振表达，从而证实了现有的主体轴模型的适用性图案化了另外两个分类群。 -Catenin定位和抑制分析已经提供了在整体聚芯片中的Neemesoderm测定中的WNT途径不太可能的作用。在更具决定性的组织化和自主规范的偏好的情况下，已经观察到甚至是诸如毒细胞分离的关键事件的替代机制的进化趋势，如异质调整（不相等）类型的螺旋发育。

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《Biology Bulletin》 |2019年第1期|14-25|共12页
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Kozin V. V.; Borisenko I. E.; Kostyuchenko R. P.;
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St Petersburg State Univ St Petersburg 199034 Russia;

St Petersburg State Univ St Petersburg 199034 Russia;

St Petersburg State Univ St Petersburg 199034 Russia;

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1. Establishment of the Axial Polarity and Cell Fate in Metazoa via Canonical Wnt Signaling: New Insights from Sponges and Annelids [J] . Kozin V. V., Borisenko I. E., Kostyuchenko R. P. Biology Bulletin . 2019,第1期

机译：通过规范的Wnt信号在后生动物中建立轴向极性和细胞命运：海绵和Annelids的新见解
2. hsa-miR29b, a critical downstream target of non-canonical Wnt signaling, plays an anti-proliferative role in non-small cell lung cancer cells via targeting MDM2 expression hsa-miR29b, a critical downstream target of non-canonical Wnt signaling, plays an anti-proliferative role in non-small cell lung cancer cells via targeting MDM2 expression hsa-miR29b, a critical downstream target of non-canonical Wnt signaling, plays an anti-proliferative role in non-small cell lung cancer cells via targeting MDM2 expression [J] . Michael G. Edwards, Katherine Vandervest, John Arcaroli, Biology Open . 2013,第7期

机译：hsa-miR29b（非经典Wnt信号的关键下游靶标）通过靶向MDM2表达在非小细胞肺癌细胞中发挥抗增殖作用hsa-miR29b（非经典Wnt信号的关键下游靶标）通过靶向MDM2表达在非小细胞肺癌细胞中的抗增殖作用hsa-miR29b（非经典Wnt信号的关键下游靶点）通过靶向MDM2表达在非小细胞肺癌细胞中发挥抗增殖作用
3. Wnt/???2-catenin signaling cell-autonomously converts non-hepatic endodermal cells to a liver fate Wnt/???2-catenin signaling cell-autonomously converts non-hepatic endodermal cells to a liver fate Wnt/???2-catenin signaling cell-autonomously converts non-hepatic endodermal cells to a liver fate [J] . Donghun Shin, Juhoon So, Benjamin L. Martin, Biology Open . 2013,第1期

机译：Wnt /β2-catenin信号传导细胞自主地将非肝内胚层细胞转化为肝命运Wnt /β2-catenin信号传导细胞自主地将非肝内胚层细胞转化为肝命运Wnt / ∑2 -catenin信号传导细胞自动将非肝内胚层细胞转化为肝脏命运
4. Roughness Surface Modification Regulates Wnt Canonical and Non-canonical Signaling Pathways in HMCS [C] . Olivares-Navarrete R., Hyzy S.L., Schwartz Z., Society for Biomaterials fall symposium 2012.;vol. 34. . 2012

机译：粗糙度表面修饰调节HMCS中Wnt的规范和非规范信号通路
5. Wnt signaling and the establishment of dorsoventral retinal polarity. [D] . Veien, Eric Sigurd. 2009

机译：Wnt信号和背腹视网膜极性的建立。
6. Non-canonical Wnt signaling orchestrates early developmental events towards mesodermal hematopoietic cell fate from human embryonic stem cells [O] . Kausalia Vijayaragavan, Eva Szabo, Marc Bossé, -1

机译：非规范WNT信号传导从人胚胎干细胞朝向中胚层造血细胞命运进行促进早期发育事件
7. An organizing activity is required for head patterning and cell fate specification in the polychaete annelid Capitella teleta: New insights into cell–cell signaling in Lophotrochozoa [O] . Amiel Aldine R., Henry Jonathan Q., Seaver Elaine C. 2013

机译：多头an小头小头中的头部模式和细胞命运规范需要组织活动：对光子虫的细胞信号传导的新见解
8. Canonical Wnt Signaling as a Specific Marker of Normal and Tumorigenic Mammary Stem Cells. [R] . B. O. Williams 2013

机译：典型Wnt信号作为正常和致瘤乳腺干细胞的特异性标记。

Establishment of the Axial Polarity and Cell Fate in Metazoa via Canonical Wnt Signaling: New Insights from Sponges and Annelids

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