Concept of T-Cell Genus as a Basis for Analysis of the Results of Cytogenetic Studies after Local Bone Marrow Exposure

Tolstykh E. I.; Vozilova A. V.; Degteva M. O.; Akleyev A. V.

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Concept of T-Cell Genus as a Basis for Analysis of the Results of Cytogenetic Studies after Local Bone Marrow Exposure

机译：T细胞属属的概念作为分析局部骨髓暴露后细胞遗传学研究结果的基础

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Evaluation of the frequency of chromosome translocations in peripheral blood T-lymphocytes is a generally accepted method of retrospective biodosimetry. Accidental contamination of the Techa River (Chelyabinsk Oblast) in 1950s with bone-seeking long-lived strontium-90 gave an opportunity to evaluate the effect of local red bone marrow (RBM) exposure on translocation formation in the peripheral T-lymphocytes of local inhabitants. The studies of the inhabitants using fluorescent in situ hybridization (FISH) showed that RBM doses calculated based on FISH results were lower than those estimated based on Sr-90 body burden measurements. The current study presents analytical review of the published data dealing with the most important processes of the T-lymphocyte development and formation of chromosome aberrations: characteristics of the main compartments where the exposure of T-cell occurs; assessment of the time spent by T-lymphocytes and their progenitors in these compartments; analysis of the dynamics of T-cell populations (proliferation and death); age-related aspects. The paper presents a concept of T-cell Genus (TG) united all the progeny of T progenitor with inheritable specific aberrations that could have developed in bone marrow.

机译：外周血T淋巴细胞中染色体易位频率的评价是一种普遍接受的回顾性生物渗透压方法。 1950年代的科技河（Chelyabinsk Oblast）意外污染了骨头寿命的锶-90给出了局部红骨髓（RBM）暴露在局部居民外周T淋巴细胞易位形成上的效果。利用荧光杂交（鱼类）的居民的研究表明，基于鱼类结果计算的RBM剂量低于基于SR-90体重测量的估计值。目前的研究提出了对涉及T淋巴细胞发育的最重要过程的公布数据和染色体畸变的分析综述：发生T细胞暴露的主要隔室的特征;在这些隔间评估T淋巴细胞及其祖细胞的时间; T细胞群体动力学分析（增殖与死亡）;与年龄有关的方面。本文呈现了T细胞属（TG）联合祖先的祖先的概念，其具有可在骨髓中发展的可遗传特异性像差。

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来源
《Biology Bulletin》 |2020年第11期|1495-1506|共12页
作者
Tolstykh E. I.; Vozilova A. V.; Degteva M. O.; Akleyev A. V.;
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作者单位

Fed Med Biol Agcy Russian Federat Urals Res Ctr Radiat Med Chelyabinsk Russia;

Fed Med Biol Agcy Russian Federat Urals Res Ctr Radiat Med Chelyabinsk Russia;

Fed Med Biol Agcy Russian Federat Urals Res Ctr Radiat Med Chelyabinsk Russia;

Fed Med Biol Agcy Russian Federat Urals Res Ctr Radiat Med Chelyabinsk Russia;

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正文语种 eng
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biodosimetry; T cells; chromosomal aberrations; bone marrow; Sr-90; Techa River; T-cell genus;

机译：生物渗透细量;T细胞;染色体像差;骨髓;SR-90;Techa河;T细胞属;

Concept of T-Cell Genus as a Basis for Analysis of the Results of Cytogenetic Studies after Local Bone Marrow Exposure

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