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首页> 外文期刊>Biology Bulletin >Antiapoptotic Effects of Caffeine, Genistein, and Verapamil in Relation to UV- Irradiated Lymphocyte Cells
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Antiapoptotic Effects of Caffeine, Genistein, and Verapamil in Relation to UV- Irradiated Lymphocyte Cells

机译：咖啡因，甘氨酸和维拉帕米与UV辐照淋巴细胞细胞相关的抗曝光作用

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摘要

Apoptosis of human lymphocytes, induced by exposure to UV light (240-390 nm) at a dose of 1510 J/m(2), is accompanied by a significant increase in the intracellular level of reactive oxygen species for 1-2 hours after irradiation. The addition of caffeine (10(-4) mol/L) and genistein (10(-6) mol/L) to UV-irradiated lymphocytes induces a decrease in the number of cells at the early stage of apoptosis by 11 and 23%, respectively, as compared to the control sample. The antiapoptotic effects of caffeine and genistein in relation to photomodified lymphocytes are related to their ability to reduce the level of reactive oxygen species in intact cells and UV-irradiated cells, as well as to inactivate hydrogen peroxide. Verapamil (10(-4) mol/L), in contrast to the effects of caffeine and genistein, does not reduce the number of lymphocytes that are at the early stage of apoptosis, as compared to that parameter for photomodified free cells, but it demonstrates the effects of reducing the levels of reactive oxygen species in immunocytes.
机译：人淋巴细胞的凋亡，通过暴露于UV光（240-390nm）的剂量为1510 j / m（2），伴随着辐射后1-2小时内的细胞内水平的显着增加1-2小时。加入咖啡因（10（-4）mol / l）和Genistein（10（-6）mol / l）到紫外线辐照淋巴细胞诱导细胞早期细胞数减少11％和23％分别与对照样品相比。咖啡因和Genistein与光掩模淋巴细胞相关的抗曝光效应与其在完整细胞和UV照射细胞中减少反应性氧物质水平的能力有关，以及灭活过氧化氢。与咖啡因和甘油酸酯的影响相比，维拉帕米（10（-4）mol / l）与凋亡的凋亡的淋巴细胞的数量相比，与光掩模的游离细胞的参数相比，不减少凋亡的早期阶段的淋巴细胞的数量，但它证明了降低免疫细胞中活性氧等水平的影响。

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