High levels of metastasis-inducing S100A4 protein and treatment outcome in early rheumatoid arthritis: data from the PERAC cohort

Senolt Ladislav; Cerezo Lucie Andres; Sumova Barbora; Pecha Ondrej; Plestilova Lenka; Forejtova Sarka; Ruzickova Olga; Husakova Marketa; Zavada Jakub; Pavelka Karel; Vencovsky Jiri; Mann Herman

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High levels of metastasis-inducing S100A4 protein and treatment outcome in early rheumatoid arthritis: data from the PERAC cohort

机译：类风湿关节炎中高水平的转移诱导S100A4蛋白和治疗结果：PERAC队列的数据

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The aim of this study was to evaluate the role of S100A4 as a biomarker in patients with early rheumatoid arthritis (RA). S100A4 levels were measured in 59 patients with early RA and in 41 healthy controls. The association between the S100A4 levels and the treatment outcome after 12 months was determined using multivariate regression analysis. Serum S100A4 levels were significantly higher in the patients with early RA than in the healthy subjects and significantly decreased after 3 months of treatment. Diseases activity at 12 months was significantly higher in female patients who had initially high levels of S100A4. Persistently high S100A4 levels predicted poor treatment outcome and S100A4 may thus represent promising biomarker for assessing treatment response in patients with RA.

机译：这项研究的目的是评估S100A4作为早期类风湿关节炎（RA）患者的生物标志物的作用。在59例早期RA患者和41例健康对照者中测量了S100A4水平。使用多元回归分析确定12个月后S100A4水平与治疗结果之间的关联。早期RA患者的血清S100A4水平显着高于健康受试者，并且在治疗3个月后明显降低。最初具有高S100A4水平的女性患者在12个月时的疾病活动明显更高。持续高水平的S100A4预测治疗效果不佳，因此S100A4可能代表有希望的生物标志物，用于评估RA患者的治疗反应。

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来源
《Biomarkers》 |2015年第8期|47-51|共5页
作者
Senolt Ladislav; Cerezo Lucie Andres; Sumova Barbora; Pecha Ondrej; Plestilova Lenka; Forejtova Sarka; Ruzickova Olga; Husakova Marketa; Zavada Jakub; Pavelka Karel; Vencovsky Jiri; Mann Herman;
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Inst Rheumatol, Prague 12850 2, Czech Republic|Charles Univ Prague, Fac Med 1, Clin Rheumatol, Prague, Czech Republic;

Inst Rheumatol, Prague 12850 2, Czech Republic;

Inst Rheumatol, Prague 12850 2, Czech Republic;

Technol Ctr ASCR, Prague, Czech Republic;

Inst Rheumatol, Prague 12850 2, Czech Republic;

Inst Rheumatol, Prague 12850 2, Czech Republic|Charles Univ Prague, Fac Med 1, Clin Rheumatol, Prague, Czech Republic;

Inst Rheumatol, Prague 12850 2, Czech Republic|Charles Univ Prague, Fac Med 1, Clin Rheumatol, Prague, Czech Republic;

Inst Rheumatol, Prague 12850 2, Czech Republic|Charles Univ Prague, Fac Med 1, Clin Rheumatol, Prague, Czech Republic;

Inst Rheumatol, Prague 12850 2, Czech Republic|Charles Univ Prague, Fac Med 1, Clin Rheumatol, Prague, Czech Republic;

Inst Rheumatol, Prague 12850 2, Czech Republic|Charles Univ Prague, Fac Med 1, Clin Rheumatol, Prague, Czech Republic;

Inst Rheumatol, Prague 12850 2, Czech Republic|Charles Univ Prague, Fac Med 1, Clin Rheumatol, Prague, Czech Republic;

Inst Rheumatol, Prague 12850 2, Czech Republic|Charles Univ Prague, Fac Med 1, Clin Rheumatol, Prague, Czech Republic;

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正文语种 eng
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Disease activity; response to treatment; rheumatoid arthritis; S100A4;

机译：疾病活动性;对治疗的反应;类风湿关节炎;S100A4;

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专利

1. Metastasis-inducing S100A4 protein is associated with the disease activity of rheumatoid arthritis [J] . Lucie Ošlejšková1 Mariam Grigorian2 Hana Hulejová1 Jiří Vencovský1 Karel Pavelka1 Jörg Klingelhöfer2 Steffen Gay3 Michel Neidhart3 Hana Brabcová4 David Suchý4 and Ladislav Šenolt1 Rheumatology . 2009,第12期

机译：转移诱导S100A4蛋白与类风湿关节炎的疾病活动有关
2. Metastasis-inducing S100A4 protein is associated with the disease activity of rheumatoid arthritis. [J] . Oslejskova L, Grigorian M, Hulejova Rheumatology . 2009,第12期

机译：转移诱导的S100A4蛋白与类风湿关节炎的疾病活性有关。
3. Serum levels of 14-3-3η protein supplement C-reactive protein and rheumatoid arthritis-associated antibodies to predict clinical and radiographic outcomes in a prospective cohort of patients with recent-onset inflammatory polyarthritis [J] . Nathalie Carrier, Anthony Marotta, Artur J. de Brum-Fernandes, Arthritis Research . 2016,第1期

机译：血清14-3-3η蛋白补充C反应蛋白和类风湿关节炎相关抗体的水平，以预测近期发病的炎性多发性关节炎患者的临床和影像学结果
4. Comparing feature selection methods for highdimensional imbalanced data: identifying rheumatoid arthritis cohorts from routine data [C] . Fabiola Fernandez-Gutierrez, Jonathan I. Kennedy, Shang-Ming Zhou, International Conference on Industrial Engineering and Systems Management . 2015

机译：高维不平衡数据的特征选择方法比较：从常规数据中识别类风湿关节炎人群
5. Complex Immune Biomarkers of Treatment Response and Disease Outcomes in Rheumatoid Arthritis. [D] . Davis, John M. 2014

机译：类风湿关节炎的治疗反应和疾病结果的复杂免疫生物标志物。
6. Decreased Circulating Visfatin Is Associated with Improved Disease Activity in Early Rheumatoid Arthritis: Data from the PERAC Cohort [O] . Ondřej Sglunda, Heřman Mann, Hana Hulejová, -1

机译：早期类风湿关节炎的循环Visfatin减少与疾病活动的改善有关：来自PERAC队列的数据
7. Metastasis-inducing S100A4 protein is associated with the disease activity of rheumatoid arthritis [O] . Oslejsková, L., Grigorian, M., Hulejová, H., 2017

机译：转移诱导S100A4蛋白与类风湿关节炎的疾病活动有关

High levels of metastasis-inducing S100A4 protein and treatment outcome in early rheumatoid arthritis: data from the PERAC cohort

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