Phosphorylated ribosomal S6 (p-rpS6) as a post-treatment indicator of HER2 signalling targeted drug resistance

Yang-Kolodji Gloria; Mumenthaler Shannon M.; Mehta Arjun; Ji Lingyun; Tripathy Debu

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Phosphorylated ribosomal S6 (p-rpS6) as a post-treatment indicator of HER2 signalling targeted drug resistance

机译：磷酸化核糖体S6（p-rpS6）作为HER2信号转导靶向药物耐药性的治疗后指标

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Objective: To identify clinically relevant predictive biomarkers of trastuzumab resistance.

机译：目的：确定曲妥珠单抗耐药的临床相关预测生物标志物。

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来源
《Biomarkers》 |2015年第8期|313-322|共10页
作者
Yang-Kolodji Gloria; Mumenthaler Shannon M.; Mehta Arjun; Ji Lingyun; Tripathy Debu;
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作者单位

Univ So Calif, Dept Med, Kenneth Norris Jr Comprehens Canc Ctr, Los Angeles, CA 90033 USA;

Univ So Calif, Ctr Appl Mol Med, Los Angeles, CA 90033 USA;

Univ So Calif, Dept Med, Kenneth Norris Jr Comprehens Canc Ctr, Los Angeles, CA 90033 USA;

Univ So Calif, Dept Prevent Med, Kenneth Norris Jr Comprehens Canc Ctr, Los Angeles, CA 90033 USA;

Univ So Calif, Dept Med, Kenneth Norris Jr Comprehens Canc Ctr, Los Angeles, CA 90033 USA|Univ Texas Houston, MD Anderson Canc Ctr, Houston, TX USA;

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正文语种 eng
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Biomarker; breast cancer; cell model; drug response; trastuzumab resistance;

机译：生物标志物;乳腺癌;细胞模型;药物反应;曲妥珠单抗;

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1. Targeting of ribosomal protein S6 to dendritic spines by in vivo high frequency stimulation to induce long-term potentiation in the dentate gyrus Targeting of ribosomal protein S6 to dendritic spines by in vivo high frequency stimulation to induce long-term potentiation in the dentate gyrus Targeting of ribosomal protein S6 to dendritic spines by in vivo high frequency stimulation to induce long-term potentiation in the dentate gyrus [J] . Kaoru Inokuchi, Itsuko Nihonmatsu, Noriaki Ohkawa, Biology Open . 2015,第11期

机译：通过体内高频刺激将核糖体蛋白S6定向到树突棘，以诱导齿状回的长期增强。通过体内高频刺激将核糖体蛋白S6定向到树突棘，诱导在齿状回中的长期增强。核糖体蛋白S6通过体内高频刺激诱导齿状回长期增强
2. The Extracellular Signal-regulated Kinase Mitogen-activated Protein Kinase/Ribosomal S6 Protein Kinase 1 Cascade Phosphorylates cAMP Response Element-binding Protein to Induce MUC5B Gene Expression via d-Prostanoid Receptor Signaling [J] . Yeon Ho Choi, Sang-Nam Lee, Hiroki Aoyagi, The Journal of biological chemistry . 2011,第39期

机译：细胞外信号调节激酶丝裂型蛋白激酶激酶/核糖体S6蛋白激酶1级联磷酸化脉冲蛋白响应元件结合蛋白，通过D-前列腺受体信号传导诱导MUC5B基因表达
3. Mechanistic Target of Rapamycin Complex 1/S6 Kinase 1 Signals Influence T Cell Activation Independently of Ribosomal Protein S6 Phosphorylation [J] . Salmond Robert J., Brownlie Rebecca J., Meyuhas Oded, The Journal of Immunology: Official Journal of the American Association of Immunologists . 2015,第10期

机译：雷帕霉素复合物1 / S6激酶1信号的机制目标独立于核糖体蛋白S6磷酸化影响T细胞活化。
4. PHOSPHORYLATED S6 KINASE AND S6 RIBOSOMAL PROTEIN ARE NOVEL BIOMARKERS OF ANTIBODY MEDIATED REJECTION IN HEART ALLOGRAFTS [C] . Fang Li, Jennifer Q. Zhang, David Gjertson, Clinical Histocompatibility Workshop. . 2010

机译：磷酸化的S6激酶和S6核糖体蛋白是心脏同种异体移植物中抗体介导的抗体的新型生物标志物
5. P90 ribosomal S6 kinase 2 (RSK2) directly phosphorylates the 5-HT-2A serotonin receptor thereby modulating signaling. [D] . Strachan, Ryan Thomas. 2009

机译：P90核糖体S6激酶2（RSK2）直接磷酸化5-HT-2A血清素受体，从而调节信号传导。
6. The Extracellular Signal-regulated Kinase Mitogen-activated Protein Kinase/Ribosomal S6 Protein Kinase 1 Cascade Phosphorylates cAMP Response Element-binding Protein to Induce MUC5B Gene Expression via d-Prostanoid Receptor Signaling [O] . Yeon Ho Choi, Sang-Nam Lee, Hiroki Aoyagi, 2011

机译：细胞外信号调节激酶丝裂原激活的蛋白激酶/核糖体S6蛋白激酶1级联磷酸化cAMP反应元件结合蛋白以通过d-前列腺素受体信号传导诱导MUC5B基因表达。
7. Mechanistic Target of Rapamycin Complex 1/S6 Kinase 1 Signals Influence T Cell Activation Independently of Ribosomal Protein S6 Phosphorylation [O] . Salmond, Robert J, Brownlie, Rebecca J, Meyuhas, Oded, 2015

机译：雷帕霉素复合物1 / s6激酶1信号的机制靶标影响T细胞活化独立于核糖体蛋白s6磷酸化

Phosphorylated ribosomal S6 (p-rpS6) as a post-treatment indicator of HER2 signalling targeted drug resistance

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