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首页> 外文期刊>Biomarkers >Meta-analysis of transforming growth factor beta receptor I 6A/9A gene polymorphism and breast cancer risk: the picture remains murky
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Meta-analysis of transforming growth factor beta receptor I 6A/9A gene polymorphism and breast cancer risk: the picture remains murky

机译：转化生长因子β受体I 6A / 9A基因多态性与乳腺癌风险的Meta分析：图像仍然模糊

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摘要

Breast cancer is currently the second most common cancer worldwide and the most frequent malignant tumor among women. However, the exact contribution of various allelic alterations remains unclear. This meta-analysis was conducted to evaluate the association of the transforming growth factor receptor I 6A/9A (TR-I 6A/9A) gene polymorphism with breast cancer risk. Relevant studies were identified from PubMed and Cochrane Library on 1 October 2013, and eligible reports were recruited and synthesized. Eleven reports that included a total of 12 studies were recruited into this meta-analysis for the association of the TR-I 6A/9A gene polymorphism and breast cancer risk. The results indicated that overall the TR-I 6A allele was associated with breast cancer risk (OR=1.33, 95% CI: 1.02-1.73, p=0.04). However, the TR-I 6A/6A and 9A/9A genotypes were not associated with an increased risk of developing breast cancer (6A/6A: OR=1.71, 95% CI: 0.95-3.08, p=0.07; 9A/9A: OR=0.82, 95% CI: 0.66-1.02, p=0.08). In the Caucasian population, no such association could be established. In conclusion, the TR-I 6A allele might represent a risk factor for breast cancer risk, but significantly larger data sets from a larger number of studies, including studies that allow ethnicity, subgroup analysis and environmental impact evaluation, are required to maximize statistical significance and meta-analysis robustness.
机译：乳腺癌是目前全球第二大最常见的癌症，也是女性中最常见的恶性肿瘤。然而，各种等位基因改变的确切贡献仍不清楚。进行这项荟萃分析，以评估转化生长因子受体I 6A / 9A（TR-1 6A / 9A）基因多态性与乳腺癌风险的相关性。 2013年10月1日从PubMed和Cochrane图书馆中鉴定了相关研究，并收集了合格的报告并进行了综合。该荟萃分析招募了11篇报道（共12项研究），用于将TR-1 6A / 9A基因多态性与乳腺癌风险相关联。结果表明总体上TR-1 6A等位基因与乳腺癌风险相关（OR = 1.33，95％CI：1.02-1.73，p = 0.04）。然而，TR-1 6A / 6A和9A / 9A基因型与罹患乳腺癌的风险增加无关（6A / 6A：OR = 1.71，95％CI：0.95-3.08，p = 0.07； 9A / 9A： OR = 0.82，95％CI：0.66-1.02，p = 0.08）。在高加索人口中，无法建立这种联系。总之，TR-1 6A等位基因可能代表了患乳腺癌的风险，但是要使统计意义最大化，就需要大量研究（包括允许种族，亚组分析和环境影响评估的研究）中的大量数据集和荟萃分析的鲁棒性。

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  • 来源
    《Biomarkers》 |2015年第8期|487-494|共8页
  • 作者

    Ou Chao; Li Hang; Liu Jiang-Hua; Drummen Gregor P. C.; Zhu Bo; Huang Ling-Sha; Huang Ying; Li Le-Qun;

  • 作者单位

    Guangxi Med Univ, Affiliated Tumor Hosp, Dept Clin Lab, Nanning 530021, Guangxi Provinc, Peoples R China;

    Guangxi Med Univ, Affiliated Tumor Hosp, Dept Phys Diag, Nanning 530021, Guangxi Provinc, Peoples R China;

    Guangxi Med Univ, Affiliated Hosp 1, Dept Emergency, Nanning 530021, Guangxi Provinc, Peoples R China;

    Bio & Nanosolut, Cellular Stress & Ageing Program, Bionanosci & Bioimaging Program, Dusseldorf, Germany;

    Guangxi Med Univ, Affiliated Tumor Hosp, Dept Clin Lab, Nanning 530021, Guangxi Provinc, Peoples R China;

    Guangxi Med Univ, Affiliated Tumor Hosp, Dept Clin Lab, Nanning 530021, Guangxi Provinc, Peoples R China;

    Guangxi Med Univ, Affiliated Tumor Hosp, Dept Clin Lab, Nanning 530021, Guangxi Provinc, Peoples R China;

    Guangxi Med Univ, Affiliated Tumor Hosp, Dept Hepatobiliary Surg, Nanning 530021, Guangxi Provinc, Peoples R China;

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  • 关键词

    6A/9A; breast cancer; gene polymorphism; meta-analysis; transforming growth factor receptor I;

    机译：6A / 9A;乳腺癌;基因多态性;meta分析;转化生长因子受体I;

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