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首页> 外文期刊>Biomarkers >Prognostic value of HOXB7 mRNA expression in human oesophageal squamous cell cancer
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Prognostic value of HOXB7 mRNA expression in human oesophageal squamous cell cancer

机译：HOXB7 mRNA表达在人食管鳞癌中的预后价值

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摘要

Objective: This study was to determine the role of HOXB7 in predicting outcomes of patients with oesophageal squamous cell cancer (OSCC). Methods: Samples were collected from 179 OSCC patients. H0XB7 mRNA expression was measured by quantitative real-time polymerase chain reaction. Results: H0XB7 mRNA expression was up-regulated in 85.1% of OSCC tumorous tissues, and correlated with age, pathological T and N category, as well as cancer-specific survival (CSS). However, subgroup analysis revealed its discernibility on CSS was only pronounced in early stage. Conclusions: H0XB7 mRNA expression might serve as a novel prognostic biomarker for resected OSCC patients in early stage.
机译：目的：本研究旨在确定HOXB7在预测食管鳞状细胞癌（OSCC）患者预后中的作用。方法：收集179例OSCC患者的样本。通过定量实时聚合酶链反应测量HOXB7 mRNA表达。结果：H0XB7 mRNA表达在85.1％的OSCC肿瘤组织中上调，并与年龄，病理性T和N类别以及癌症特异性生存率（CSS）相关。但是，亚组分析显示，其在CSS上的可分辨性仅在早期才被宣布。结论：H0XB7 mRNA表达可能是早期切除的OSCC患者的一种新的预后生物标志物。

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  • 来源
    《Biomarkers》 |2013年第4期|297-303|共7页
  • 作者

    Xuan Xie; Shui-shen Zhang; Jing Wen; Hong Yang; Kong-jia Luo; Fu Yang; Yi Hu; Jian-hua Fu;

  • 作者单位

    State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, Guangzhou, People's Republic of China,Guangdong Esophageal Cancer Research Institute, Guangzhou, People's Republic of China,Department of Thoracic Surgery, Sun Yat-sen University Cancer Center, Guangzhou, People's Republic of China;

    State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, Guangzhou, People's Republic of China,Guangdong Esophageal Cancer Research Institute, Guangzhou, People's Republic of China,Department of Thoracic Surgery, Sun Yat-sen University Cancer Center, Guangzhou, People's Republic of China;

    State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, Guangzhou, People's Republic of China,Guangdong Esophageal Cancer Research Institute, Guangzhou, People's Republic of China;

    State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, Guangzhou, People's Republic of China,Guangdong Esophageal Cancer Research Institute, Guangzhou, People's Republic of China,Department of Thoracic Surgery, Sun Yat-sen University Cancer Center, Guangzhou, People's Republic of China;

    State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, Guangzhou, People's Republic of China,Guangdong Esophageal Cancer Research Institute, Guangzhou, People's Republic of China,Department of Thoracic Surgery, Sun Yat-sen University Cancer Center, Guangzhou, People's Republic of China;

    State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, Guangzhou, People's Republic of China,Guangdong Esophageal Cancer Research Institute, Guangzhou, People's Republic of China,Department of Thoracic Surgery, Sun Yat-sen University Cancer Center, Guangzhou, People's Republic of China;

    State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, Guangzhou, People's Republic of China,Guangdong Esophageal Cancer Research Institute, Guangzhou, People's Republic of China,Department of Thoracic Surgery, Sun Yat-sen University Cancer Center, Guangzhou, People's Republic of China;

    State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, Guangzhou, People's Republic of China,Guangdong Esophageal Cancer Research Institute, Guangzhou, People's Republic of China,Department of Thoracic Surgery, Sun Yat-sen University Cancer Center, Guangzhou, People's Republic of China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Biomarker; gene expression; H0XB7; oesophageal cancer; outcomes;

    机译：生物标志物基因表达;H0XB7;食道癌;结果;

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