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Relationship between HLA-G gene polymorphism and the susceptibility of esophageal cancer in Kazakh and Han nationality in Xinjiang

机译：哈萨克族和汉族人HLA-G基因多态性与食管癌易感性的关系

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摘要

Objective: To explore the association between polymorphism of the human leukocyte antigen G (HLA-G) and susceptibility of esophageal carcinoma (EC) in Kazakh and Han nationality in Xinjiang. Methods: The 14bp deletion/insertion (rs16375) and 0105N (rs41557518) of HLA-G genotyping were determined by PCR and PCR-RFLP, respectively in 239 patients and 467 controls. Results: There was a 2.69-fold (P_c=0.04, 95% Cl: 1.30-5.55) increased risk of developing EC in individuals with the -14 bp/-14 bp genotype (rs16375) compared with those carrying +14 bp/+14 bp genotype in Kazakh after Bonferroni correction, there was no association of 0105N (rs41557518) both in Kazak and Han population. And there was a 2.82-fold (P_c=0.04, 95% Cl: 1.32-6.04) increased risk of developing EC in individuals with -14bp/-14bp and C/C genotypes compared with those who had +14bp/+14bp and C/C genotypes in Kazakh. Conclusions: The study demonstrates that EC is associated with polymorphism of HLA-G14 bp in Chinese Kazak population. The 14 bp deletion/insertion of HLA-G gene may play a role in EC susceptibility of Kazakh.
机译：目的：探讨新疆哈萨克族和汉族人白细胞抗原G（HLA-G）多态性与食管癌易感性的关系。方法：采用PCR和PCR-RFLP技术分别对239例患者和467例对照者进行了HLA-G基因分型的14bp缺失/插入（rs16375）和0105N（rs41557518）。结果：与携带+14 bp / +的个体相比，具有-14 bp / -14 bp基因型（rs16375）的个体发生EC的风险增加了2.69倍（P_c = 0.04，95％Cl：1.30-5.55）。在Bonferroni校正后，哈萨克人的基因型为14 bp，在哈萨克族和汉族人群中都没有0105N（rs41557518）的关联。与具有+ 14bp / + 14bp和C基因型的个体相比，具有-14bp / -14bp和C / C基因型的个体发生EC的风险增加了2.82倍（P_c = 0.04，95％Cl：1.32-6.04）。哈萨克人的/ C基因型。结论：研究表明EC与中国哈萨克族人群HLA-G14 bp多态性有关。 HLA-G基因的14 bp缺失/插入可能在哈萨克斯坦的EC易感性中起作用。

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  • 来源
    《Biomarkers》 |2012年第1期|p.9-15|共7页
  • 作者

    Yan Chen; Xiu-jing Gao; Yan-chao Deng; Hui-xia Zhang;

  • 作者单位

    Department of Toxicology, School of Public Health, Xinjiang Medical University, Urumqi, Xinjiang, China;

    Department of Toxicology, School of Public Health, Xinjiang Medical University, Urumqi, Xinjiang, China;

    Department of thoracic surgery, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, China;

    Department of Toxicology, School of Public Health, Xinjiang Medical University, Urumqi, Xinjiang, China;

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  • 正文语种 eng
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  • 关键词

    human 8-hydroxyguanine glycosylase; genetic polymorphism; esophageal cancer; kazakh;

    机译：人8-羟基鸟嘌呤糖基化酶;遗传多态性食道癌;哈萨克人;

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