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Immunologic profile of excessive body weight

机译:体重过重的免疫学特征

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The purpose of this paper is to identify immunologic hallmarks of excessive bodyweight. The analysis is based on 176 adults (106 women, 70 men) who participated in a nested case-control study in Italy. All participants were healthy at the time of blood collection and aged between 36 and 75 years. We employed multivariate analysis of variance and a nonparametric Bayesian additive regression tree approach along with a receiver operating characteristic (ROC) curve analysis to determine the immunologic signature of excessive body weight (i.e., obesity and overweight). Interleukin 8 (IL-8), IL-10, interferon y, and inducible protein 10 were shown to be predictive of excessive body weight with an area under the ROC curve of 71% (p< 0.0002). We propose that by using this profile-based approach to define immunologic signatures, it might be possible to identify unique immunologic hallmarks of specific types of obesity.
机译:本文的目的是确定体重过重的免疫学标志。该分析基于参加意大利嵌套病例对照研究的176名成人(106名女性,70名男性)。所有参与者在采血时都是健康的,年龄在36至75岁之间。我们采用方差的多变量分析和非参数贝叶斯加性回归树方法以及接收者操作特征(ROC)曲线分析来确定体重过重(即肥胖和超重)的免疫学特征。白细胞介素8(IL-8),IL-10,干扰素γ和可诱导蛋白10被证明可预测体重过重,ROC曲线下面积为71%(p <0.0002)。我们建议通过使用这种基于配置文件的方法来定义免疫学特征,可能有可能确定特定类型肥胖的独特免疫学特征。

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