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首页> 外文期刊>Biomarkers >Do polymorphisms in XRCC4 influence prostate cancer susceptibility in North Indian population?
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Do polymorphisms in XRCC4 influence prostate cancer susceptibility in North Indian population?

机译：XRCC4中的多态性是否会影响北印度人口的前列腺癌易感性？

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Objective: XRCC4 play a key role in nonhomologous end-joining repair pathway. Alterations in DNA repair gene have been shown to reduce DNA repair capacity thereby inflicting carcinogenesis. Methods: In a hospital-based case-control study, 192 prostate cancer (PCa) and 224 healthy controls. They were genotyped for XRCC4 G-1394T (rs6869366), intron 3 (rs28360071) Intron 7 (rs28360317) and intron 7 (rs1805377), polymorphisms using polymerase chain reaction-restriction fragment length polymorphism. Result Carriers of GG genotype of rs6869366 were at reduced risk. Del/Del of rs28360071 and 28360317 demonstrated increased risk. The haplotype analysis was observed to be associated with a significant increase in PCa risk. Combined genotype of rs6869366, rs28360071 and rs1805377 have shown significant risk with high Gleason grade. Conclusion: Our results suggested that the variant genotype of XRCC4 rs28360071 and rs28360317 and haplotype analysis may be associated with PCa risk.
机译：目的：XRCC4在非同源末端连接修复途径中起关键作用。 DNA修复基因的改变已显示降低DNA修复能力，从而引起癌变。方法：在一项基于医院的病例对照研究中，对192名前列腺癌（PCa）和224名健康对照进行了研究。使用聚合酶链反应-限制性片段长度多态性对它们的基因型进行了XRCC4 G-1394T（rs6869366），内含子3（rs28360071），内含子7（rs28360317）和内含子7（rs1805377）的多态性分析。结果rs6869366 GG基因型携带者的风险降低。 rs28360071和28360317的Del / Del显示风险增加。观察到单倍型分析与PCa风险的显着增加有关。 rs6869366，rs28360071和rs1805377的组合基因型在高格里森等级下显示出显着风险。结论：我们的结果表明，XRCC4 rs28360071和rs28360317的变异基因型和单倍型分析可能与PCa风险有关。

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  • 来源
    《Biomarkers》 |2011年第3期|p.236-242|共7页
  • 作者

    Raju K. Mandal; Vibha Singh; Rakesh Kapoor; R.D. Mittal;

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    Department of Urology and Renal Transplantation, Sanjay Gandhi Post Graduate Institute of Medical Sciences,Lucknow, Uttar Pradesh, India;

    Department of Urology and Renal Transplantation, Sanjay Gandhi Post Graduate Institute of Medical Sciences,Lucknow, Uttar Pradesh, India;

    Department of Urology and Renal Transplantation, Sanjay Gandhi Post Graduate Institute of Medical Sciences,Lucknow, Uttar Pradesh, India;

    Department of Urology and Renal Transplantation, Sanjay Gandhi Post Graduate Institute of Medical Sciences,Lucknow, Uttar Pradesh, India;

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