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首页> 外文期刊>Biomarkers >Urinary α-GST and π-GST for prediction of dialysis requirement or in-hospital death in established acute kidney injury
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Urinary α-GST and π-GST for prediction of dialysis requirement or in-hospital death in established acute kidney injury

机译：尿α-GST和π-GST预测已确立的急性肾损伤中的透析需求或医院内死亡

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摘要

Context: Urinary a-glutathione S-transferase (a-GST) and π-glutathione S-transferase (π-GST) are promising proximal and distal tubular leakage markers for early detection of acute kidney injury (AKI). Objective: To examine the performance of these markers for predicting the composite of dialysis requirement or in-hospital death in patients with an established diagnosis of AKI. Materials and methods: Prospective cohort study of 245 adults with AKI. A single urinary α-GSTand π-GSTmeasurement was obtained at time of nephrology consultation. Results: Overall, urinary π-GST performed better than α-GST for prediction of dialysis requirement (AUC 0.59 vs. 0.56), and the composite outcome (AUC 0.58 vs. 0.56). In subgroup analyses, π-GST displayed better discrimination for prediction of dialysis requirement in patients with baseline eGFR <60mL/min/1.73 m~2 (AUC 0.61) and oliguria (AUC 0.72). Similarly, α-GST performed better in patients with stage-1 (AUC 0.66) and stage-2 AKI (AUC 0.80). Conclusions: In patients with an established diagnosis of AKI, a single urinary π-GST measurement performed better than α-GST at predicting dialysis requirement or death, but neither marker had good prognostic discrimination.
机译：背景：尿液α-谷胱甘肽S-转移酶（a-GST）和π-谷胱甘肽S-转移酶（π-GST）是有望用于早期发现急性肾损伤（AKI）的近端和远端肾小管渗漏标志物。目的：检查这些标志物在预测已确诊为AKI的患者中的透析需求或院内死亡复合情况的表现。材料和方法：245名AKI成人的前瞻性队列研究。肾脏科会诊时进行了一次尿α-GST和π-GST测定。结果：总体上，尿π-GST在预测透析需求（AUC 0.59 vs. 0.56）和综合结局（AUC 0.58 vs. 0.56）方面表现优于α-GST。在亚组分析中，对于基线eGFR <60mL / min / 1.73 m〜2（AUC 0.61）和少尿（AUC 0.72）的患者，对于预测透析需求的预测，π-GST表现出更好的区分度。同样，α-GST在1期（AUC 0.66）和2期AKI（AUC 0.80）的患者中表现更好。结论：在确诊为AKI的患者中，单次尿π-GST测定在预测透析需求或死亡方面比α-GST更好，但两种标记都没有良好的预后判别。

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  • 来源
    《Biomarkers》 |2011年第8期|p.709-717|共9页
  • 作者

    Victor F. Seabra; Mary C. Perianayagam; Hocine Tighiouart; Orfeas Liangos; Oscar F. P. dos Santos; Bertrand L. Jaber;

  • 作者单位

    Kidney and Dialysis Research Laboratory, St. Elizabeth's Medical Center, Boston, MA,Department of Medicine, Tufts University School of Medicine, Boston, MA,Division of Nephrology, Federal University of Sao Paulo, Brazil;

    Kidney and Dialysis Research Laboratory, St. Elizabeth's Medical Center, Boston, MA,Department of Medicine, Tufts University School of Medicine, Boston, MA;

    Biostatistics Research Center, Tufts Medical Center, Boston, MA,Department of Medicine, Tufts University School of Medicine, Boston, MA;

    Department of Medicine, Tufts University School of Medicine, Boston, MA,III. Med. Klinik, Klinikum Coburg, Coburg, Germany;

    Division of Nephrology, Federal University of Sao Paulo, Brazil;

    Kidney and Dialysis Research Laboratory, St. Elizabeth's Medical Center, Boston, MA,Department of Medicine, Tufts University School of Medicine, Boston, MA;

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  • 正文语种 eng
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  • 关键词

    acute kidney injury; acute renal failure; biomarker; glutathione S-transferase; epidemiology; prognosis;

    机译：急性肾损伤;急性肾功能衰竭;生物标志物谷胱甘肽S-转移酶;流行病学预后;

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