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首页> 外文期刊>Biomarkers >Bone mineral density and genetic markers involved in three connected pathways (focal adhesion, actin cytoskeleton regulation and cell cycle): the CUMAGAS-BMD information system
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Bone mineral density and genetic markers involved in three connected pathways (focal adhesion, actin cytoskeleton regulation and cell cycle): the CUMAGAS-BMD information system

机译：骨矿物质密度和遗传标记物涉及三个相关途径（粘着斑，肌动蛋白细胞骨架调控和细胞周期）：CUMAGAS-BMD信息系统

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摘要

The focal adhesion, the actin cytoskeleton and cell-cycle are connected pathways and their genes are implicated in the pathogenesis of low BMD. Data from 211 studies that investigated the association between BMD and gene variants involved in these pathways were catalogued in a web-based information system and analyzed. In individual studies, significant association was found for 16 variants in lumbar spine, 11 in femoral neck and 5 in hip. In meta-analysis, significant results were shown for the variants COL1A1 rs1800012 (in lumbar spine and femoral neck), COL1A1 rs1107946 (in lumbar spine), TGFB1 rs1982073 (in femoral neck and hip) and TGFB1 rs1800469 (in lumbar spine).
机译：粘着斑，肌动蛋白的细胞骨架和细胞周期是连接的途径，它们的基因与低骨密度的发病有关。在基于Web的信息系统中对来自211项研究的数据进行了分类，这些研究调查了BMD与这些途径中涉及的基因变异之间的关联。在个别研究中，发现腰椎的16种变异，股骨颈的11种变异和髋部的5种变异之间存在显着相关性。在荟萃分析中，对于变体COL1A1 rs1800012（在腰椎和股骨颈中），COL1A1 rs1107946（在腰椎中），TGFB1 rs1982073（在股骨颈和臀部中）和TGFB1 rs1800469（在腰椎中）显示了显着结果。

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  • 来源
    《Biomarkers》 |2011年第8期|p.698-708|共11页
  • 作者

    Elias Zintzaras; Chrysoula Doxani; Dimitrios C. Ziogas; Theodoros Mprotsis; Paraskevi Rodopoulou; Theofilos Karachalios;

  • 作者单位

    Department of Biomathematics, University of Thessaly School of Medicine, Larissa, Greece,Center for Clinical Evidence Synthesis, Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Tufts University School of Medicine, Boston, MA, USA;

    Department of Biomathematics, University of Thessaly School of Medicine, Larissa, Greece,Department of Orthopedics, University of Thessaly School of Medicine, Larissa, Greece;

    Department of Orthopedics, University of Thessaly School of Medicine, Larissa, Greece;

    Department of Biomathematics, University of Thessaly School of Medicine, Larissa, Greece;

    Department of Biomathematics, University of Thessaly School of Medicine, Larissa, Greece;

    Department of Orthopedics, University of Thessaly School of Medicine, Larissa, Greece,Institute for Biomedical Research and Technology, BIOMED/CERETETH, Larissa, Greece;

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  • 正文语种 eng
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  • 关键词

    bone mineral density; information system; meta-analysis; genetic polymorphism; focal adhesion; actin cytoskeleton regulation; cell cycle pathways;

    机译：骨密度;信息系统;荟萃分析遗传多态性粘连肌动蛋白细胞骨架调节;细胞周期途径;

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