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A functional variation in pre-microRNA-196a is associated with susceptibility of esophageal squamous cell carcinoma risk in Chinese Han

机译：pre-microRNA-196a的功能变异与中国汉族人食管鳞状细胞癌易感性相关

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摘要

MicroRNAs (miRNAs) are small, non-protein-coding RNAs that function as tumour suppressors or oncogenes. A single nucleotide change in the sequence of pre-miRNA can affect miRNA expression, so single-nucleotide polymorphisms (SNPs) in pre-miRNA may be biomarkers for biomedical applications. In this study, we performed a genetic association study between the SNP (rs11614913) in pre-miRNA-196a and esophageal squamous cell carcinoma (ESCC) susceptibility in a case-control study. We found that the homozygote CC of this SNP increased the risk of ESCC compared with the homozygote TT and the risk was more evident among smokers than non-smokers. Therefore, this functional SNP may be a biomarker for ESCC outcome.
机译：微小RNA（miRNA）是小的非蛋白质RNA，起着抑癌作用或致癌基因的作用。 pre-miRNA序列中的单个核苷酸变化会影响miRNA的表达，因此pre-miRNA中的单核苷酸多态性（SNP）可能是生物医学应用的生物标记。在这项研究中，我们在病例对照研究中进行了前miRNA-196a中的SNP（rs11614913）与食管鳞状细胞癌（ESCC）敏感性之间的遗传关联研究。我们发现，与纯合子TT相比，该SNP的纯合子CC增加了ESCC的风险，吸烟者中的风险比不吸烟者更为明显。因此，此功能性SNP可能是ESCC结果的生物标志物。

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  • 来源
    《Biomarkers》 |2010年第7期|p.614-618|共5页
  • 作者

    Kai Wang1; Hong Guo; Huamei Hu; GangXiong; Xingying Guan; Juan Li; XueqingXu; Kang Yang; Yun Bai;

  • 作者单位

    Department of Medical Genetics, Department of Basic Medicine, Third Military Medical University, Chongqing, PR China;

    rnDepartment of Medical Genetics, Department of Basic Medicine, Third Military Medical University, Chongqing, PR China;

    rnDepartment of Medical Genetics, Department of Basic Medicine, Third Military Medical University, Chongqing, PR China;

    rnDepartment of Thoracic and Cardiac Surgery, Southwest Hospital, Third Military Medical University, Chongqing, PR China;

    rnDepartment of Medical Genetics, Department of Basic Medicine, Third Military Medical University, Chongqing, PR China;

    rnDepartment of Medical Genetics, Department of Basic Medicine, Third Military Medical University, Chongqing, PR China;

    rnDepartment of Medical Genetics, Department of Basic Medicine, Third Military Medical University, Chongqing, PR China;

    rnDepartment of Thoracic and Cardiac Surgery, Southwest Hospital, Third Military Medical University, Chongqing, PR China;

    rnDepartment of Medical Genetics, Department of Basic Medicine, Third Military Medical University, Chongqing 400038, PR China;

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  • 正文语种 eng
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  • 关键词

    SNP; miRNA-196a; esophageal cancer;

    机译：SNP;miRNA-196a;食道癌;

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