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Potential implications of matrix metalloproteinase-9 in assessment and treatment of coronary artery disease

机译：基质金属蛋白酶9在评估和治疗冠状动脉疾病中的潜在意义

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摘要

Background: Matrix metalloproteinase (MMP)-9, a member of the MMP superfamily is consistently implicated in the pathophysiology of atherosclerosis and plaque rupture, the most common mechanism responsible for acute coronary syndrome (ACS).rnAim: To summarize the role of MMP-9 in atherosclerosis and its potential implications in assessment and treatment of coronary artery disease (CAD).rnMethods: We reviewed the PubMed database for relevant data regarding the role of MMP-9 in the pathophysiology of atherosclerosis. In the light of these data, we postulate potential implications of MMP-9 in the management and treatment of CAD.rnResults and conclusions: Existing data strongly support the role of MMP-9 in plaque destabilization and rupture. Based on the current knowledge, MMP-9 can potentially serve as a diagnostic biomarker in ACS and a prognostic biomarker in ACS and chronic CAD patients. MMP-9 is reduced by therapies that are associated with favourable outcome in atherosclerosis and thus may serve as a surrogate biomarker of treatment efficacy. However, large morbidity and mortality trials are still required to confirm that MMP-9 reduction is associated with improved outcome independent of the traditional risk factors (i.e. low-density lipoprotein cholesterol). Given its role in plaque rupture, inhibition of MMP-9 may promote plaque stabilization and consequently reduce cardiovascular events. Yet, the efficacy and safety of MMPs inhibitors should be first studied in preclinical models of atherosclerosis.
机译：背景：基质金属蛋白酶（MMP）-9是MMP超家族的一员，始终参与动脉粥样硬化和斑块破裂的病理生理，动脉粥样硬化和斑块破裂是导致急性冠脉综合征（ACS）的最常见机制。rn目标：总结MMP-方法9：研究动脉粥样硬化及其对冠状动脉疾病（CAD）评估和治疗的潜在意义。方法：我们审查了PubMed数据库中有关MMP-9在动脉粥样硬化病理生理中的作用的相关数据。根据这些数据，我们推测MMP-9在CAD的治疗和治疗中的潜在意义。结果与结论：现有数据强烈支持MMP-9在斑块失稳和破裂中的作用。基于当前的知识，MMP-9可能在ACS中用作诊断生物标志物，并在ACS和慢性CAD患者中用作预后生物标志物。与动脉粥样硬化的良好预后相关的疗法可降低MMP-9，因此可作为治疗功效的替代生物标志物。但是，仍然需要进行大量的发病率和死亡率试验，以证实MMP-9的降低与改善预后相关，而与传统的危险因素（即低密度脂蛋白胆固醇）无关。鉴于其在斑块破裂中的作用，抑制MMP-9可以促进斑块稳定并因此减少心血管事件。然而，应首先在动脉粥样硬化的临床前模型中研究MMPs抑制剂的功效和安全性。

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  • 来源
    《Biomarkers》 |2009年第2期|118-129|共12页
  • 作者

    Yuval Konstantino; Tu T. Nguyen; Robert Wolk; Robert J. Aiello; Steven G. Terra; David A. Fryburg;

  • 作者单位

    Cardiovascular and Metabolic Diseases, Pfizer Global Research and Development, Groton, CT, USA Department of Cardiology, Rabin Medical Center, Petah-Tikva, and Sackler, Faculty of Medicine, Tel-Aviv University, Israel;

    Cardiovascular and Metabolic Diseases, Pfizer Global Research and Development, Groton, CT, USA;

    Cardiovascular and Metabolic Diseases, Pfizer Global Research and Development, Groton, CT, USA;

    Cardiovascular and Metabolic Diseases, Pfizer Global Research and Development, Groton, CT, USA;

    Cardiovascular and Metabolic Diseases, Pfizer Global Research and Development, Groton, CT, USA;

    Cardiovascular and Metabolic Diseases, Pfizer Global Research and Development, Groton, CT, USA;

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  • 正文语种 eng
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  • 关键词

    atherosclerosis; acute coronary syndrome; MMPs; MMP-9; MMP inhibitors;

    机译：动脉粥样硬化急性冠状动脉综合征;MMP;MMP-9;MMP抑制剂;

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