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Activity and function in lung injuries due to sulphur mustard

机译：硫芥子气对肺损伤的活性和功能

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Aim. Pulmonary complications are known to occur in over half the patients exposed to sulphur mustard. Many studies have focused on the clinical complications, often ignoring the pathogenesis of sulphur mustard. Also, the reasons for the variable severity of lung injuries caused by sulphur mustard are unclear. Hence, the current study was performed to evaluate the correlation between superoxide dismutase (SOD) and catalase (CAT) activity and pulmonary function in patients exposed to sulphur mustard. Methods. Our study was a comparative cross-sectional survey. Two hundred and fifty incident survivors were selected from the Sardasht population who were exposed to sulphur mustard in 1987. A control group from non-exposed civilians was also selected. We used a pulmonary function test, and SOD and CAT activity was measured in these groups. Results. The mean SOD activity in the healthy control group (70.5 ± 10.8 U ml~(-1)) was higher than in the moderate-to-severe group (67.0 ± 6.1 U ml~(-1)) (p<0.001, one-tail ANOVA, least significant difference (LSD) post hoc). The mean activity in the mild group (72.5 ± 6.9 U ml~(-1)) was no higher than in the healthy control group (70.5 ± 10.8 U ml~(-1)) (p = 0.095 one-tail ANOVA, LSD post hoc). The mean CAT activity in the healthy control group (4.9 ± 1.5 U ml~(-1)) was lower than in the moderate-to-severe group (8.0±1.8 U ml~(-1)) (p< 0.001, one-tail ANOVA, LSD post hoc) and in the mild group (7.5 ± 1.5 U ml~(-1)) (p = 0.012 one-tail ANOVA, LSD post hoc). Conclusion. According to our findings, it is reasonable to hypothesize that re-establishment of the activation inactivation or oxidant antioxidant balance in favour of the activation and antioxidant balances would be useful as a therapeutic strategy to suppress pathological mechanisms underlying lung injuries.
机译：目标。已知有一半以上的硫芥子气患者发生肺部并发症。许多研究集中在临床并发症上，常常忽略了硫芥子气的发病机理。同样，尚不清楚硫芥子引起的肺部损伤严重程度不同的原因。因此，本研究旨在评估暴露于硫芥末的患者中的超氧化物歧化酶（SOD）和过氧化氢酶（CAT）活性与肺功能之间的相关性。方法。我们的研究是一项比较横断面调查。 1987年从Sardasht人群中选出了250名幸存者，他们于1987年暴露于硫芥末。还选择了一个未接触平民的对照组。我们使用了肺功能测试，并在这些组中测量了SOD和CAT活性。结果。健康对照组的平均SOD活性（70.5±10.8 U ml〜（-1））高于中度至重度组（67.0±6.1 U ml〜（-1））（p <0.001，1尾方差分析，事后最小显着差异（LSD）。轻度组（72.5±6.9 U ml〜（-1））的平均活性不高于健康对照组（70.5±10.8 U ml〜（-1））（p = 0.095单尾方差分析，LSD事后）。健康对照组的平均CAT活性（4.9±1.5 U ml〜（-1））低于中重度组（8.0±1.8 U ml〜（-1））（p <0.001，1尾组ANOVA，LSD事后）和轻度组（7.5±1.5 U ml〜（-1））（p = 0.012一尾ANOVA，LSD事后）。结论。根据我们的发现，可以合理地假设活化失活或氧化剂抗氧化剂平衡的重建有利于活化和抗氧化剂平衡，将作为抑制肺部损伤的病理机制的治疗策略很有用。

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  • 来源
    《Biomarkers》 |2008年第8期|728-733|共6页
  • 作者

    MAJID SHOHRATI; MOSTAFA GHANEI; NAWAB SHAMSPOUR; MAHVASH JAFARI;

  • 作者单位

    Research Center of Chemical Injuries, Baqyiatallah Medical Sciences University, Tehran, Iran;

    Research Center of Chemical Injuries, Baqyiatallah Medical Sciences University, Tehran, Iran;

    Research Center of Chemical Injuries, Baqyiatallah Medical Sciences University, Tehran, Iran;

    Research Center of Chemical Injuries, Baqyiatallah Medical Sciences University, Tehran, Iran;

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  • 正文语种 eng
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  • 关键词

    sulphur mustard; superoxide dismutase; catalase; lung injury;

    机译：硫芥末;超氧化物歧化酶;过氧化氢酶肺损伤;

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