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首页> 外文期刊>Biomarkers >The evolving systemic and local biomarker milieu at different stages of disease progression in rat collagen-induced arthritis
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The evolving systemic and local biomarker milieu at different stages of disease progression in rat collagen-induced arthritis

机译：大鼠胶原蛋白诱发的关节炎在疾病进展的不同阶段的全身和局部生物标志物环境的演变

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摘要

Rats with collagen-induced arthritis (CIA) were necropsied on 14 occasions from 4 days after induction to 27 days after disease onset to evaluate the kinetics of local (joint protein extracts) and systemic (serum) levels of inflammatory and pro-erosive factors. Systemic increases in α1 acid glycoprotein and KC/GRO together with systemic and local enrichment of interleukin (IL)-1β, IL-6, CCL2, transforming growth factor (TGF)-β and elevated IL-1α and IL-18 in joint extracts preceded the onset of clinical disease. Systemic upregulation of IL-1β, IL-6, TGF-β CCL2, RANKL and prostaglandin E_2 (PGE_2) during acute and/or chronic CIA coincided with systemic leukocytosis and a CD4+ T-cell increase in blood and spleen. In contrast, progression of joint erosions during clinical CIA was associated with intra-articular increases in IL-1α/β, IL-6, IL-18, CCL2, KC/GRO and RANKL, and a dramatic decline in osteoprotegerin (OPG). These data indicate that systemic and local events in inflammatory arthritis can be discrete processes, driven by multiple cellular and humoral mediators with distinct temporospatial profiles.
机译：从诱导后第4天到疾病发作后第27天，对胶原性关节炎（CIA）大鼠进行14次尸检，以评估炎症因子和促侵蚀因子的局部（关节蛋白提取物）和全身（血清）水平的动力学。关节提取物中α1酸性糖蛋白和KC / GRO的全身性增加以及白介素（IL）-1β，IL-6，CCL2，转化生长因子（TGF）-β的全身和局部富集以及升高的IL-1α和IL-18在临床疾病发作之前。在急性和/或慢性CIA期间，IL-1β，IL-6，TGF-βCCL2，RANKL和前列腺素E_2（PGE_2）的系统上调与系统性白细胞增多和血液和脾脏中CD4 + T细胞增加相吻合。相反，在临床CIA期间关节糜烂的进展与IL-1α/β，IL-6，IL-18，CCL2，KC / GRO和RANKL的关节内增加以及骨保护素（OPG）的急剧下降有关。这些数据表明，炎症性关节炎的全身性和局部性事件可能是离散的过程，由具有不同颞pat骨分布的多种细胞和体液介质驱动。

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