...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Biomarkers >Biological monitoring among benzene-exposed workers in Bangalore city, India
【24h】

Biological monitoring among benzene-exposed workers in Bangalore city, India

机译：印度班加罗尔市苯接触工人的生物监测

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Environmental and biological monitoring was carried out in the winter season of 2004 for 30 gasoline station workers (study subjects) and 30 office workers (controls) of Bangalore city, India. Personal air sampling was carried out in the breathing zone of workers using an Anasorb CSC sorbent tube (SKC 226-01) fitted to the low-flow personal samplers (PCXR4 and pocket pump Model No. 210-1002) at a flow rate of 200 ml min~(-1) during the shift work of 8 h. The benzene content adsorbed in the sorbent tube (SKC 226-01) was desorbed with 1 ml of benzene-free carbon disulfide on a developing vibrator and later analysed by Trace GC fitted with MXT-624 column and flame ionization detector. The mean time weighted average benzene concentration found among study and controls was 1.10 ± 1.08 and 0.070 ± 0.035 mg m~(-3), respectively. Biological monitoring for benzene exposure was performed by measuring trans, trans muconic acid (t,t-MA) in the end shift urine samples using HPLC-UV technique. End-shift urine samples (1 ml) were adjusted to pH 7-9 with phosphate buffer pH 7.4 passed through the preconditioned Q-SAX anion-exchange cartridge and the (t,t-MA) is extracted with 10% acetic acid and later analysed by HPLC-UV detection The mean t,t-MA found among study and controls were 563.16 ± 281.81 and 266.88 ± 110.65 μg g~(-1) creatinine. About 50% of the study subjects (15) have higher t,t-MA values than the biological exposure index of the American Conference of Government Industrial Hygienist (ACGIH). Correlation is significant at 5% level (p < 0.05) between personal air benzene concentration and urinary t,t-MA in the study group. Based on these findings, the t,t-MA can be used as a biomarker for benzene exposure.
机译：2004年冬季，对印度班加罗尔市的30名加油站工作人员（研究对象）和30名上班族（控制人员）进行了环境和生物监测。使用安装在低流量个人采样器（PCXR4和型号210-1002的袖珍泵）上的Anasorb CSC吸附剂管（SKC 226-01）在工人的呼吸区域中进行个人空气采样，流速为200 8小时的轮班工作中，ml min〜（-1）。用1 ml无苯二硫化碳在显影振动器上解吸吸附剂管（SKC 226-01）中吸附的苯含量，然后通过配备MXT-624色谱柱和火焰离子检测器的Trace GC进行分析。在研究和对照组中发现的平均时间加权平均苯浓度分别为1.10±1.08和0.070±0.035 mg m〜（-3）。通过使用HPLC-UV技术测量终移尿液样品中的反式，反式粘康酸（t，t-MA）来进行苯接触量的生物监测。用磷酸盐缓冲液pH 7.4通过预调节的Q-SAX阴离子交换柱将终排尿液样品（1 ml）的pH值调节为7-9，然后用10％的乙酸萃取（t，t-MA），然后HPLC-UV检测法分析在研究和对照组中发现的平均t，t-MA为563.16±281.81和266.88±110.65μgg〜（-1）肌酐。大约50％的研究对象（15）的t，t-MA值高于美国政府工业卫生学家会议（ACGIH）的生物暴露指数。在研究组中，个人空气中苯的浓度与尿中t，t-MA的相关性在5％水平（p <0.05）。基于这些发现，t，t-MA可用作苯暴露的生物标志物。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号