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首页> 外文期刊>Biomedical and Health Informatics, IEEE Journal of >Covariation of Depressive Mood and Spontaneous Physical Activity in Major Depressive Disorder: Toward Continuous Monitoring of Depressive Mood
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Covariation of Depressive Mood and Spontaneous Physical Activity in Major Depressive Disorder: Toward Continuous Monitoring of Depressive Mood

机译：重度抑郁症患者抑郁情绪与自发体育活动的协变：持续监测抑郁情绪

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The objective evaluation of depressive mood is considered to be useful for the diagnosis and treatment of depressive disorders. Thus, we investigated psychobehavioral correlates, particularly the statistical associations between momentary depressive mood and behavioral dynamics measured objectively, in patients with major depressive disorder (MDD) and healthy subjects. Patients with MDD () and healthy subjects () wore a watch-type computer device and rated their momentary symptoms using ecological momentary assessment. Spontaneous physical activity in daily life, referred to as locomotor activity, was also continuously measured by an activity monitor built into the device. A multilevel modeling approach was used to model the associations between changes in depressive mood scores and the local statistics of locomotor activity simultaneously measured. We further examined the cross validity of such associations across groups. The statistical model established indicated that worsening of the depressive mood was associated with the increased intermittency of locomotor activity, as characterized by a lower mean and higher skewness. The model was cross validated across groups, suggesting that the same psychobehavioral correlates are shared by both healthy subjects and patients, although the latter had significantly higher mean levels of depressive mood scores. Our findings suggest the presence of robust as well as common associations between momentary depressive mood and behavioral dynamics in healthy individuals and patients with depression, which may lead to the continuous monitoring of the pathogenic processes (from healthy states) and pathological states of MDD.
机译：抑郁情绪的客观评估被认为可用于抑郁症的诊断和治疗。因此，我们调查了重度抑郁症（MDD）患者和健康受试者的心理行为相关性，尤其是瞬时抑郁情绪与客观测量的行为动力学之间的统计联系。患有MDD的患者（）和健康受试者（）佩戴手表式计算机设备，并使用生态瞬时评估对他们的瞬时症状进行评分。日常生活中的自发性体育活动，也称为运动活动，也通过设备内置的活动监视器进行连续测量。多级建模方法用于建模抑郁情绪评分变化与同时测量的运动活动局部统计之间的关联。我们进一步研究了跨群体的这种关联的交叉有效性。建立的统计模型表明，抑郁情绪的恶化与运动活动的间歇性增加有关，其特征是平均数较低和偏度较高。该模型在各组之间进行了交叉验证，这表明健康受试者和患者均具有相同的心理行为相关性，尽管后者的抑郁情绪评分平均水平明显较高。我们的研究结果表明，在健康个体和抑郁症患者中，短暂的抑郁情绪与行为动力学之间存在牢固且常见的关联，这可能导致对MDD的致病过程（来自健康状态）和病理状态的持续监测。

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