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首页> 外文期刊>IEEE Transactions on Biomedical Engineering >A Palm-Sized Cryoprobe System With a Built-In Thermocouple and Its Application in an Animal Model of Epilepsy
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A Palm-Sized Cryoprobe System With a Built-In Thermocouple and Its Application in an Animal Model of Epilepsy

机译：内置热电偶的掌型冷冻探针系统及其在癫痫动物模型中的应用

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Objective: The purpose of this study is to propose a palm-sized cryoprobe system with a built-in thermocouple (TC) for highly accurate and sensitive temperature measurements, and to verify the effectiveness of the system. Methods: Conventional cryoprobe systems based on the boiling effect of a refrigerant have triple coaxial tubes. In the proposed system, the outer and middle coaxial tubes are made of two different metals that are welded only at the probe tip, thereby forming a TC. The thermoelectric properties of the built-in TC and measurement accuracy were investigated in agar in a constant-temperature chamber. The system was also applied in a penicillin G-induced rat brain epilepsy model. Results: We verified that the built-in TC has appropriate thermoelectric properties and that the system more accurately and sensitively measured transient temperature changes at the probe tip wall compared to conventional systems, showing the cooling performance of the system. In the rat model, epileptiform activities disappeared on freezing, and reliable cell necrosis was achieved at an end temperature of -45.2 +/- 1.6 degrees C. Conclusions: The proposed system is suitable for reliable cryosurgery. Significance: The system is probably to be valuable for clarifying the relationship between freezing temperature and cell necrosis in vivo.
机译：目的：本研究的目的是提出一种具有内置热电偶（TC）的手掌大小的低温探头系统，以进行高精度和灵敏的温度测量，并验证该系统的有效性。方法：基于制冷剂沸腾作用的常规低温探头系统具有三根同轴管。在所提出的系统中，外部和中间同轴管由两种不同的金属制成，仅在探针尖端焊接，从而形成TC。在恒温室内的琼脂中研究了内置TC的热电性能和测量精度。该系统还应用于青霉素G诱导的大鼠脑癫痫模型中。结果：我们验证了内置TC具有适当的热电特性，并且与传统系统相比，该系统能够更准确，更灵敏地测量探头尖端壁处的瞬态温度变化，从而显示出系统的冷却性能。在大鼠模型中，癫痫样活动在冷冻时消失，并且在-45.2 +/- 1.6摄氏度的最终温度下实现了可靠的细胞坏死。结论：所提出的系统适用于可靠的冷冻手术。启示：该系统对于阐明体内冷冻温度和细胞坏死之间的关系可能是有价值的。

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