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首页> 外文期刊>IEEE Transactions on Biomedical Engineering >Evaluation of Optical Coherence Tomography for the Measurement of the Effects of Activators and Anticoagulants on the Blood Coagulation In Vitro
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Evaluation of Optical Coherence Tomography for the Measurement of the Effects of Activators and Anticoagulants on the Blood Coagulation In Vitro

机译：光学相干断层扫描技术的评估，用于测量激活剂和抗凝剂对体外血液凝固的影响

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摘要

Optical properties of human blood during coagulation were studied using optical coherence tomography (OCT) and the parameter of clotting time derived from the 1/$e$ light penetration depth $(d_{1/e})$ versus time was developed in our previous work. In this study, in order to know if a new OCT test can characterize the blood-coagulation process under different treatments in vitro, the effects of two different activators (calcium ions and thrombin) and anticoagulants, i.e., acetylsalicylic acid (ASA, a well-known drug aspirin) and melagatran (a direct thrombin inhibitor), at various concentrations are evaluated. A swept-source OCT system with a 1300 nm center wavelength is used for detecting the blood-coagulation process in vitro under a static condition. A dynamic study of $d_{1/e}$ reveals a typical behavior due to coagulation induced by both calcium ions and thrombin, and the clotting time is concentration-dependent. Dose-dependent ASA and melagatran prolong the clotting times. ASA and melagatran have different effects on blood coagulation. As expected, melagatran is much more effective than ASA in anticoagulation by the OCT measurements. The OCT assay appears to be a simple method for the measurement of blood coagulation to assess the effects of activators and anticoagulants, which can be used for activator and anticoagulant screening.
机译：使用光学相干断层扫描（OCT）研究了人体血液在凝结过程中的光学特性，并从1 / <公式式=“ inline”> $ e $ 得出凝血时间参数光线穿透深度 $（d_ {1 / e}）$ 与时间的关系是在我们之前的工作中开发的。在这项研究中，为了了解新的OCT测试是否可以表征体外治疗下的凝血过程，两种不同的激活剂（钙离子和凝血酶）和抗凝剂，即乙酰水杨酸（ASA，评估了各种浓度下的已知药物阿司匹林（Aspirin）和蜜加群（melagatran）（直接凝血酶抑制剂）。中心波长为1300 nm的扫频OCT系统用于在静态条件下体外检测凝血过程。对 $ d_ {1 / e} $ 进行的动态研究揭示了钙离子和凝血酶诱导的凝结所致的典型行为。 ，凝血时间取决于浓度。剂量依赖性ASA和美拉加群延长了凝血时间。 ASA和美加仑对血液凝固有不同的影响。如预期的那样，通过OCT测量，美拉加群在抗凝方面比ASA有效得多。 OCT分析似乎是一种简单的方法，用于测量凝血功能，以评估活化剂和抗凝剂的作用，可用于活化剂和抗凝剂的筛选。

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