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首页> 外文期刊>IEEE Transactions on Biomedical Engineering >Robust Predictive Control Strategy Applied for Propofol Dosing Using BIS as a Controlled Variable During Anesthesia
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Robust Predictive Control Strategy Applied for Propofol Dosing Using BIS as a Controlled Variable During Anesthesia

机译：麻醉期间采用BIS作为控制变量的鲁棒预测控制策略应用于丙泊酚剂量

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摘要

This paper presents the application of predictive control to drug dosing during anesthesia in patients undergoing surgery. The performance of a generic predictive control strategy in drug dosing control, with a previously reported anesthesia-specific control algorithm, has been evaluated. The robustness properties of the predictive controller are evaluated with respect to inter- and intrapatient variability. A single-input (propofol) single-output (bispectral index, BIS) model of the patient has been assumed for prediction as well as for simulation. A set of 12 patient models were studied and interpatient variability and disturbances are used to assess robustness of the controller. Furthermore, the controller guarantees the stability in a desired range. The applicability of the predictive controller in a real-life environment via simulation studies has been assessed.
机译：本文介绍了预测控制在手术患者麻醉期间给药的应用。已经评估了通用预测控制策略在药物剂量控制中的性能，以及先前报告的麻醉特异性控制算法。关于患者之间和患者内部的可变性，评估了预测控制器的鲁棒性。假定患者的单输入（异丙酚）单输出（双频谱指数，BIS）模型可用于预测和模拟。研究了一组12种患者模型，并使用了患者间的变异性和干扰来评估控制器的鲁棒性。此外，控制器保证了所需范围内的稳定性。已经通过仿真研究评估了预测控制器在现实环境中的适用性。

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