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首页> 外文期刊>Biomedical Microdevices >Biomimetic Hydrogels For Biosensor Implant Biocompatibility: Electrochemical Characterization Using Micro-disc Electrode Arrays (mdeas)
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Biomimetic Hydrogels For Biosensor Implant Biocompatibility: Electrochemical Characterization Using Micro-disc Electrode Arrays (mdeas)

机译：用于生物传感器植入物的仿生水凝胶生物相容性：使用微盘电极阵列（mdeas）的电化学表征

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摘要

Our interest is in the development of engineered microdevices for continuous remote monitoring of intramuscular lactate, glucose, pH and temperature during post-traumatic hemorrhaging. Two important design considerations in the development of such devices for in vivo diagnostics are discussed; the utility of micro-disc electrode arrays (MDEAs) for electrochemical biosensing and the application of biomimetic, bioactive poly(HEMA)-based hydrogel composites for implant biocompatibility. A poly(HEMA)-based hydrogel membrane containing polyethylene glycol (PEG) was UV cross-linked with tetraethyleneglycol diacrylate following application to MDEAs (50 urn discs) and to 250 μm diameter gold electrodes within 8-well culture ware. Cyclic voltamme-try (CV) of the MDEAs revealed a reduction in the apparent diffusion coefficient of ferrocenemonocarboxylic acid (FcCO_2H), from 6.68×10~(-6) to 6.74×10~(-6) cm~2/s for the uncoated and 6 urn thick hydrogel coated devices, respectively. Single frequency (4 kHz) temporal impedance measurements of the hydrogels in the 8-well culture ware showed a reversible 5% change in the absolute impedance of the hydrogels when exposed to a pH change between 6.1 to 7.2 and a 20% drop between pH 6.1 and 8.8.
机译：我们的兴趣是开发可在创伤后出血期间连续远程监测肌肉内乳酸，葡萄糖，pH和温度的微型设备。讨论了这种用于体内诊断的设备的开发中的两个重要的设计考虑因素。微盘电极阵列（MDEA）用于电化学生物传感的实用性，以及基于仿生，生物活性聚（HEMA）的水凝胶复合材料在植入物生物相容性方面的应用。将含有聚乙二醇（PEG）的基于聚（HEMA）的水凝胶膜与四丙烯酸二乙二醇酯进行UV交联，然后将其应用于8孔培养皿中的MDEA（50微米圆盘）和直径250μm的金电极。 MDEAs的循环伏安法（CV）显示二茂铁单羧酸（FcCO_2H）的表观扩散系数从6.68×10〜（-6）cm〜2 / s降低到6.74×10〜（-6）cm〜2 / s。未涂覆的和6微米厚的水凝胶涂覆的设备。在8孔培养皿中对水凝胶的单频（4 kHz）时间阻抗测量表明，当暴露于6.1至7.2的pH值变化和pH 6.1的20％下降时，水凝胶的绝对阻抗可逆变化为5％。和8.8。

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