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首页> 外文期刊>Biomedical signal processing and control >A Method to Minimise the Impact of ECG Marker Inaccuracies on the Spatial QRS-T angle: Evaluation on 1,512 Manually Annotated ECGs
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A Method to Minimise the Impact of ECG Marker Inaccuracies on the Spatial QRS-T angle: Evaluation on 1,512 Manually Annotated ECGs

机译：一种最小化ECG标记不准确对空间QRS-T角度影响的方法：1,512手动注释的心电图评估

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摘要

The spatial QRS-T angle (QRS-Ta) derived from the vectorcardiogram (VCG) is a strong risk predictor for ventricular arrhythmia and sudden cardiac death with potential use for mass screening. Accurate QRS-Ta estimation in the presence of ECG delineation errors is crucial for its deployment as a prognostic test. Our study assessed the effect of inaccurate QRS and T-wave marker placement on QRS-Ta estimation and proposes a robust method for its calculation.Reference QRS-Ta measurements were derived from 1,512 VCGs manually annotated by three expert reviewers. We systematically changed onset and offset timings of QRS and T-wave markers to simulate inaccurate placement. The QRS-Ta was recalculated using a standard approach and our proposed algorithm, which limits the impact of VCG marker inaccuracies by defining the vector origin as an interval preceding QRS-onset and redefines the beginning and end of QRS and T-wave loops.Using the standard approach, mean absolute errors (MAE) in peak QRS-Ta were 40% and sensitivity and precision in the detection of abnormality (1051 were 80% and 65% respectively, when QRS-onset was delayed or QRS-offset anticipated 15 ms. Using our proposed algorithm, MAE for peak QRS-Ta were reduced to 4% and sensitivity and precision of abnormality were 94% for inaccuracies up to +/- 15 ms. Similar results were obtained for mean QRS-Ta.In conclusion, inaccuracies of QRS and T-wave markers can significantly influence the QRS-Ta. Our proposed algorithm provides robust QRS-Ta measurements in the presence of inaccurate VCG annotation, enabling its use in large datasets.
机译：源自瓣膜心图（VCG）的空间QRS-T角度（QRS-TA）是心间心律失常的强风险预测因子，并且突然心脏死亡潜在用于质量筛选。在ECG描绘误差存在下准确的QRS-TA估计对于其部署是预后测试至关重要。我们的研究评估了QRS和T波标记放置对QRS-TA估计的不准确的影响，并提出了一种计算的稳健方法。引用QRS-TA测量来自三个专家评论者手动注释的1,512 VCG。我们系统地改变了QRS和T波标记的起点和偏移定时，以模拟不准确的放置。使用标准方法和我们所提出的算法重新计算QRS-TA，这通过将VCG标记不准确性定义为QRS-ONSET之前的间隔来限制VCG标记不准确性的影响，并重新定义QRS和T波环的开头和结束。使用标准方法，平均峰值QRS-TA中的绝对误差（MAE）> 40％，在QRS发作延迟或QRS时，检测异常（> 1051分别为<80％和<65％），灵敏度和精度分别为<80％和<65％。偏移预期> 15毫秒。使用我们所提出的算法，MAE用于峰值QRS-TA减少到<4％，异常的敏感性和精度为94％，可因+/- 15毫秒而获得类似的结果。为平均QRS获得了类似的结果-TA.IN结论，QRS和T波标记的不准确会影响QRS-TA。我们所提出的算法在不准确的VCG注释存在下提供强大的QRS-TA测量，从而使其在大型数据集中使用。

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  • 来源
    《Biomedical signal processing and control》 |2021年第2期|102305.1-102305.8|共8页
  • 作者

    Young William J.; van Duijvenboden Stefan; Ramirez Julia; Jones Aled; Tinker Andrew; Munroe Patricia B.; Lambiase Pier D.; Orini Michele;

  • 作者单位

    Queen Mary Univ London Barts & London Sch Med & Dent William Harvey Res Inst Clin Pharmacol Dept London EC1M 6BQ England|Barts Hlth NHS Trust St Bartholomews Hosp Barts Heart Ctr London EC1A 7BE England;

    Queen Mary Univ London Barts & London Sch Med & Dent William Harvey Res Inst Clin Pharmacol Dept London EC1M 6BQ England|UCL Inst Cardiovasc Sci London WC1E 6BT England;

    Queen Mary Univ London Barts & London Sch Med & Dent William Harvey Res Inst Clin Pharmacol Dept London EC1M 6BQ England|UCL Inst Cardiovasc Sci London WC1E 6BT England;

    Queen Mary Univ London Barts & London Sch Med & Dent William Harvey Res Inst Clin Pharmacol Dept London EC1M 6BQ England;

    Queen Mary Univ London Barts & London Sch Med & Dent William Harvey Res Inst Clin Pharmacol Dept London EC1M 6BQ England;

    Queen Mary Univ London Barts & London Sch Med & Dent William Harvey Res Inst Clin Pharmacol Dept London EC1M 6BQ England;

    UCL Inst Cardiovasc Sci London WC1E 6BT England|Barts Hlth NHS Trust St Bartholomews Hosp Barts Heart Ctr London EC1A 7BE England;

    UCL Inst Cardiovasc Sci London WC1E 6BT England|Barts Hlth NHS Trust St Bartholomews Hosp Barts Heart Ctr London EC1A 7BE England;

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  • 正文语种 eng
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  • 关键词

    Electrocardiogram; Vectorcardiogram; Spatial QRS-T angle; Automatic analysis; Population distribution;

    机译：心电图;矢量心电图;空间QRS-T角度;自动分析;人口分布;

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