Adjusting for covariate effects on classification accuracy using the covariate-adjusted receiver operating characteristic curve

Holly Janes and Margaret S. Pepe

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Adjusting for covariate effects on classification accuracy using the covariate-adjusted receiver operating characteristic curve

机译：使用经协变量调整的接收器工作特性曲线来调整对分类精度的协变量影响

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Recent scientific and technological innovations have produced an abundance of potentialnmarkers that are being investigated for their use in disease screening and diagnosis. In evaluatingnthese markers, it is often necessary to account for covariates associated with the markernof interest. Covariates may include subject characteristics, expertise of the test operator, testnprocedures or aspects of specimen handling. In this paper, we propose the covariate-adjustednreceiver operating characteristic curve, a measure of covariate-adjusted classification accuracy.nNonparametric and semiparametric estimators are proposed, asymptotic distribution theory isnprovided and finite sample performance is investigated. For illustration we characterize thenage-adjusted discriminatory accuracy of prostate-specific antigen as a biomarker for prostatencancer.

机译：最近的科学和技术创新产生了大量潜在的标记物，正在对其进行疾病筛查和诊断的研究。在评估这些标记时，通常需要考虑与感兴趣标记相关的协变量。协变量可能包括主题特征，测试操作员的专业知识，测试过程或样本处理方面。本文提出了协变量调整后的接收器工作特性曲线，衡量了协变量调整后的分类精度。提出了非参数估计器和半参数估计器，提供了渐近分布理论并研究了有限样本性能。为了说明，我们表征了前列腺特异性抗原的时间调整后的鉴别准确性，作为前列腺癌的生物标志物。

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来源
《Biometrika》 |2009年第2期|p.371-382|共12页
作者
Holly Janes and Margaret S. Pepe;
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作者单位

Division of Public Health Sciences, Fred Hutchinson CancerResearch Center, 1100 Fairview Avenue North,Seattle, Washington 98109, U.S.A.hjanes@scharp.org mspepe@u.washington.edu;

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正文语种 eng
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关键词
Classification accuracy; Covariate effect; Receiver operating characteristic curve; Sensitivity; Specificity.;

机译：分类精度;协变量效应;接收器工作特性曲线;灵敏度;专一性;

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专利

1. Adjusting for covariate effects on classification accuracy using the covariate-adjusted receiver operating characteristic curve [J] . HOLLY JANES, MARGARET S. PEPE Biometrika . 2009,第2期

机译：使用经协变量调整的接收器工作特性曲线来调整对分类精度的协变量影响
2. Comparison of Axillary, Tympanic and Rectal Body Tem-peratures Using a Covariate-Adjusted Receiver Operating Characteristic Approach [J] . Iranian red crescent medical journal . 2010,第3期

机译：使用协变量调整的接收器工作特征方法比较腋窝，鼓膜和直肠体温
3. A statistical approach to the evaluation of covariate effects on the receiver operating characteristic curves of diagnostic tests in glaucoma. [J] . Medeiros FA, Sample PA, Zangwill LM, Investigative ophthalmology & visual science . 2006,第6期

机译：一种统计方法，用于评估对青光眼诊断测试的受试者工作特征曲线的协变量影响。
4. Sets of receiver operating characteristic curves and their use in the evaluation of multi-class classification [C] . Stephan M. Winkler, Michael Affenzeller, Stefan Wagner, Annual conference on Genetic and evolutionary computation;Conference on Genetic and evolutionary computation . 2006

机译：接收机工作特性曲线集及其在多类分类评估中的应用
5. Enhancing Statistician Power: Flexible Covariate-adjusted Semiparametric Inference for Randomized Studies with Multivariate Outcomes. [D] . Stephens, Alisa Jane. 2012

机译：增强统计学家的力量：具有多元结果的随机研究的灵活协变量调整半参数推理。
6. Adjusting for covariate effects on classification accuracy using the covariate-adjusted receiver operating characteristic curve [O] . Holly Janes, Margaret S. Pepe -1

机译：使用经协变量调整的接收器工作特性曲线来调整对分类精度的协变量影响
7. Adjusting for Covariate Effects on Classification Accuracy Using the Covariate-Adjusted ROC Curve [O] . Janes Holly, Pepe Margaret S. 2006

机译：使用协变量调整后的ROC曲线调整协变量对分类精度的影响

Adjusting for covariate effects on classification accuracy using the covariate-adjusted receiver operating characteristic curve

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