Cyanocobalamin (vitamin B12) conjugates with enhanced solubility.

WangX; WeiL; KotraLP

首页> 外文期刊>Bioorganic and Medicinal Chemistry >Cyanocobalamin (vitamin B12) conjugates with enhanced solubility.

【24h】

Cyanocobalamin (vitamin B12) conjugates with enhanced solubility.

机译：氰钴胺（维生素B12）具有增强的溶解性。

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Cyanocobalamin (vitamin B12) is an essential nutrient as well as a very useful carrier in drug delivery. Conjugates of vitamin B12 are investigated due to their wide range of therapeutic applications. We report the synthesis of six vitamin B12 conjugates, and the effect of conjugation on their solubilities and stabilities in various media. We reveal here that vitamin B12 can be released readily if a 2'-hydroxyl group is conjugated rather than the 5'-hydroxyl group, and the solubility (thus the equivalents of vitamin B12) could be enhanced as much as 19-fold, by simple conjugates such as glycolates. Findings disclosed here provide insights into the reactivities of vitamin B12 conjugates, the design of future prodrugs and similar conjugated moieties using vitamin B12.

机译：氰钴胺（维生素B12）是必需的营养素，也是药物输送中非常有用的载体。由于维生素B12的缀合物具有广泛的治疗应用，因此对其进行了研究。我们报告了六种维生素B12共轭物的合成，以及共轭对它们在各种介质中的溶解度和稳定性的影响。我们在这里揭示，如果结合了2'-羟基而不是5'-羟基，则维生素B12可以很容易地释放，并且溶解度（因此，维生素B12的当量）可以提高19倍，简单的结合物，例如乙醇酸酯。此处公开的发现提供了对维生素B12共轭物的反应性，未来前药的设计以及使用维生素B12的类似共轭部分的见解。

著录项

来源
《Bioorganic and Medicinal Chemistry》 |2007年第4期|P.1780-1787|共8页
作者
WangX; WeiL; KotraLP;
展开▼
作者单位

Center for Molecular Design and Preformulations, Toronto General Research Institute, University Health Network, Toronto, Ont., Canada.;

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类药学;生物化学;
关键词
Vitamin B 12; VITAMIN B12 MEASUREMENT; Solubility; hydroxyl group; 维生素B12; 溶解度;

机译：Vitamin B 12;VITAMIN B12 MEASUREMENT;Solubility;hydroxyl group;维生素B12;溶解度;

相似文献

外文文献
中文文献
专利

1. Cyanocobalamin (vitamin B12) conjugates with enhanced solubility. [J] . Wang X, Wei L, Kotra LP Bioorganic and medicinal chemistry . 2007,第4期

机译：氰钴胺（维生素B12）具有增强的溶解性。
2. The cytotoxic effect of the vitamin B12 inhibitor cyanocobalamin (c-lactam), and a review of other vitamin B12 antagonists. [J] . Matthews JH, Matthews JH Leukemia and lymphoma . 1998,第1a2期

机译：维生素B12抑制剂氰钴胺素（c-lactam）的细胞毒性作用，以及其他维生素B12拮抗剂的综述。
3. Effects of Chemical and Physical Enhancement Techniques on Transdermal Delivery of Cyanocobalamin (Vitamin B12) In Vitro [J] . Ajay K. Banga, Haripriya Kalluri, Ye Yang Pharmaceutics . 2011,第3期

机译：化学和物理增强技术对Cyanocobalamin（Vitamin B12）透皮递送的影响
4. ENHANCEMENT OF REDUCTIVE DECHLORINATION OF TETRACHLOROETHENE BY INTERACTION BETWEEN NANO-SIZED ZERO VALENT IRON AND VITAMIN B12: EFFECT OF PHYSICOCHEMICAL FACTOR [C] . Amir A., Lee W. International symposium on halogenated persistent organic pollutants . 2009

机译：纳米零价铁与维生素B12相互作用增强四氯乙烯的还原脱氯作用：物理化学因子的作用
5. Overexpression, purification, and characterization of the Pseudomonas denitrificans and Salmonella typhimurium gene products in vitamin B12 biosynthesis, structural analysis of vitamin B12 intermediates, and enzymatic synthesis of factor S3. [D] . Ozaki, Shin-Ichi. 1992

机译：维生素B12生物合成中反硝化假单胞菌和鼠伤寒沙门氏菌基因产物的过表达，纯化和表征，维生素B12中间体的结构分析以及因子S3的酶促合成。
6. Effects of Chemical and Physical Enhancement Techniques on Transdermal Delivery of Cyanocobalamin (Vitamin B12) In Vitro [O] . Ye Yang, Haripriya Kalluri, Ajay K. Banga 2011

机译：化学和物理增强技术对氰钴胺素（维生素B12）透皮递送的影响
7. Effects of Chemical and Physical Enhancement Techniques on Transdermal Delivery of Cyanocobalamin (Vitamin B12) In Vitro [O] . Ajay K. Banga, Haripriya Kalluri, Ye Yang 2011

机译：化学和物理增强技术对氰钴胺素（维生素B12）透皮递送的影响

Cyanocobalamin (vitamin B12) conjugates with enhanced solubility.

摘要

著录项

相似文献

相关主题

期刊订阅