New anticancer bastadin alkaloids from the sponge Dendrilla cactos

A. Vijender Reddy; K. Ravinder; M. Narasimhulu; A. Sridevi; N. Satyanarayana; Anand K. Kondapi; Y. Venkateswarlu

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New anticancer bastadin alkaloids from the sponge Dendrilla cactos

机译：海绵仙人掌中新的抗癌巴斯塔丁生物碱

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Two new bastadin alkaloids, bastadins-22 (1) and 23 (2), together with six known bastadins, bastadins-6 (3), -12 (4) (formerly basatadin-9), -14 (5), -15 (6), -16 (7), -19 (8) and a common steroid cholesterol were isolated from the sponge Dendrilla cactos. The structures of the isolates were established by the study of extensive spectroscopic analysis (1D and 2D NMR and MS data). Anticancer activity of the isolates has been carried out against Sup-T_1 cancer cells (T cell lymphoma).

机译：两个新的bastadin生物碱，basastins 22（1）和23（2），以及六个已知的bastadins，bastadins 6（3），-12（4）（以前为basatadin-9），-14（5），-15 （6），-16（7），-19（8）和常见的类固醇胆固醇是从海绵Dendrilla仙人掌中分离出来的。分离物的结构是通过广泛的光谱分析（1D和2D NMR和MS数据）的研究确定的。分离物的抗癌活性已针对Sup-T_1癌细胞（T细胞淋巴瘤）进行。

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来源
《Bioorganic and Medicinal Chemistry》 |2006年第13期|p.4452-4457|共6页
作者
A. Vijender Reddy; K. Ravinder; M. Narasimhulu; A. Sridevi; N. Satyanarayana; Anand K. Kondapi; Y. Venkateswarlu;
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作者单位

Natural Products Laboratory, Organic Chemistry Division-I, Indian Institute of Chemical Technology, Hyderabad 500 007, India;

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正文语种 eng
中图分类药学;生物化学;
关键词
bastadin alkaloids; sponge; dendrilla cactos; anticancer activity; sup-T_1 cancer cells (T cell lymphoma);

机译：巴斯达丁生物碱;海绵;仙人掌;抗癌活性;sup-T_1癌细胞（T细胞淋巴瘤）;

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专利

1. New anticancer bastadin alkaloids from the sponge Dendrilla cactos [J] . A. Vijender Reddy, K. Ravinder, M. Narasimhulu, Bioorganic and medicinal chemistry . 2006,第13期

机译：海绵仙人掌中新的抗癌巴斯塔丁生物碱
2. New family and genus for Dendrilla-like sponges with characters of Verongiida. Part I redescription of Dendrilla lacunosa Hentschel 1912, diagnosis of the new family Ernstillidae and Ernstilla n. g. [J] . Vacelet Jean, Erpenbeck Dirk, Diaz Cristina, Zoologischer Anzeiger . 2019,第期

机译：新的家庭和属的Dendrilla样海绵，verongiida的特征。第一部分Dendrilla Lacunosa Hentschel 1912的重新描述，诊断新的家庭Ernstillidae和Ernstilla n。 G。
3. Spongian Diterpenoids Derived from the Antarctic Sponge Dendrilla antarctica Are Potent Inhibitors of the Leishmania Parasite [J] . Shilling Andrew J., Witowski Christopher G., Maschek J. Alan, Journal of natural products . 2020,第5期

机译：来自南极海绵南极洲南极洲的Spongian二萜是Leishmania寄生虫的有效抑制剂
4. SOLUTION OF THE MULTI-STEP ASSEMBLY OF CATHARANTHUS ROSEUS ANTICANCER ALKALOIDS. [C] . Vincenzo De Luca, Yang Qu Conference on biochemical and molecular engineering . 2019

机译：樟脑玫瑰抗癌剂碱的多步法解决方案。
5. I. An investigation of the diterpenoid chemistry of the Caribbean gorgonians Erythropodium caribaeorum and Briareum sp. II. Studies on the chemistry of the sponges Jaspis stellifera from Guam and Jaspis sp. from New Guinea. III. New bastadin-type metabolites from the sponge Ianthella basta from Guam. [D] . Pordesimo, Evamarie Oquendo. 1989

机译：一，对加勒比高地鳄加勒比红藻和Briareum sp。的二萜化学的研究。二。关岛和Jaspis sp。的海绵Jaspis stellifera的化学研究。来自新几内亚。三，来自关岛的Ianthella basta海绵中的新bastadin型代谢物。
6. Bioactivity of Spongian Diterpenoid Scaffolds from the Antarctic Sponge Dendrilla antarctica [O] . Alexandre Bory, Andrew J. Shilling, Jessie Allen, 2020

机译：南极海绵牙髓南极海绵状二萜支架的生物活性
7. Population substructure and signals of divergent adaptive selection despite admixture in the sponge Dendrilla antarctica from shallow waters surrounding the Antarctic Peninsula [O] . Carlos Leiva, Sergi Taboada, Nathan J. Kenny, 2019

机译：尽管南极半岛围绕浅水区的海绵德内德南极洲的海绵德内德南极突出，但分歧适应选择的人口次结构和信号

New anticancer bastadin alkaloids from the sponge Dendrilla cactos

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