New naphthylcombretastatins. Modifications on the ethylene bridge.

Sanchez Maya AB; Perez Melero C; Salvador N; Pelaez R; Caballero E; Medarde M

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New naphthylcombretastatins. Modifications on the ethylene bridge.

机译：新萘甲他汀。乙烯桥上的修饰。

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摘要

Compounds with three aromatic systems, carrying a 2-naphthalene and a 3,4,5-trimethoxyphenyl moieties bonded to five-membered, six-membered or fused heterocycles display potent cytotoxic effect and inhibition of tubulin polymerization, in agreement with their structural similarity to combretastatins and their heterocyclic analogues.

机译：具有三个芳族系统的化合物，它们带有键合至五元，六元或稠合杂环的2-萘和3,4,5-三甲氧基苯基部分，与它们的结构相似性相一致，显示出强大的细胞毒性作用和对微管蛋白聚合的抑制作用。康布雷他汀及其杂环类似物。

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来源
《Bioorganic and Medicinal Chemistry》 |2005年第6期|P.2097-2107|共11页
作者
Sanchez Maya AB; Perez Melero C; Salvador N; Pelaez R; Caballero E; Medarde M;
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作者单位

Laboratorio de Quimica Organica y Farmaceutica, Facultad de Farmacia, Universidad de Salamanca, Campus Miguel de Unamuno, 37007 Salamanca, Spain.;

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原文格式 PDF
正文语种 eng
中图分类基础医学;
关键词
New; Ethylenes; agreement; Polymerization; Tubulin; 乙烯类; 微管蛋白;

机译：New;Ethylenes;agreement;Polymerization;Tubulin;乙烯类;微管蛋白;

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New naphthylcombretastatins. Modifications on the ethylene bridge.

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