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首页> 外文期刊>Bioprocess and Biosystems Engineering >Polymersomes as nanoreactors for preparative biocatalytic applications: current challenges and future perspectives
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Polymersomes as nanoreactors for preparative biocatalytic applications: current challenges and future perspectives

机译：聚合物囊体作为制备型生物催化应用的纳米反应器：当前的挑战和未来的前景

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摘要

Polymersomes are hollow, spherical vesicles that are surrounded by a polymer membrane. The applied polymer must be amphiphilic to promote self-assembly in aqueous solution. At the same time, the polymer composition is highly versatile, which leads to diverse properties in terms of chemical and mechanical stability, membrane permeability and the ability to functionalize the membrane. By encapsulating chemical or biological substances within the polymersomes, drug delivery systems, cell mimetics or catalytic nanoreactors can be assembled. Whereas drug delivery systems and cell mimetics based on polymersomes have been reviewed excessively, we lay focus on the current challenges and perspectives of polymersomes as nanoreactors for preparative biocatalytic applications. We discuss the importance of membrane properties for the use of polymersomes for synthetic applications and highlight advances in polymersome production and membrane functionalization. Finally, we summarize recent applications of polymersomes as nanoreactors, discuss the associated challenges and disclose future requirements and perspectives for the industrial use of polymersomes as nanoreactors.
机译：聚合物小体是被聚合物膜围绕的空心球形囊泡。所施加的聚合物必须是两亲的，以促进在水溶液中的自组装。同时，该聚合物组合物是高度通用的，这导致在化学和机械稳定性，膜渗透性和使膜功能化的能力方面的多种特性。通过将化学或生物物质包封在多聚体中，可以组装药物递送系统，细胞模拟物或催化纳米反应器。尽管已经对基于聚合物囊泡的药物递送系统和细胞模拟物进行了全面审查，但我们将重点放在聚合物囊泡作为制备型生物催化应用纳米反应器的当前挑战和观点上。我们讨论了膜性质对于将聚合物囊泡用于合成应用的重要性，并重点介绍了聚合物囊泡生产和膜功能化方面的进展。最后，我们总结了聚合物囊泡作为纳米反应器的最新应用，讨论了相关的挑战，并披露了聚合物囊泡作为纳米反应器的工业用途的未来要求和观点。

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