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Dependence of fungal characteristics on seed morphology and shear stress in bioreactors

机译：真菌特性对生物反应器种子形态和切应力的依赖性

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摘要

The fungal morphology during submerged cultivations has a profound influence on the overall performance of bioreactors. In this research, glucoamylase production by Aspergillus niger has been taken as a model to improve more insights. The morphology engineering could be conducted effectively by changing the seed morphology, as well as specific power input. During the fed-batch cultivations, pellet formation under milder shear stress field helped to reduce the broth viscosity, thus relieving oxygen limitation and promoting the enzyme production. Furthermore, we found that the relation between the shear stress field, which was characterized by energy dissipation rate/circulation function (EDCF), and enzyme activity was consistent with quadratic parabola, which threw light on the process optimization and scale-up for industrial enzyme production.
机译：淹没培养过程中的真菌形态对生物反应器的整体性能有深远的影响。在这项研究中，黑曲霉生产葡糖淀粉酶已被用作提高更多见解的模型。通过改变种子的形态以及比功率输入，可以有效地进行形态工程。在分批补料培养过程中，在较温和的剪切应力场下沉淀形成有助于降低肉汤粘度，从而减轻了氧气的限制并促进了酶的产生。此外，我们发现以能量耗散率/循环函数（EDCF）为特征的剪切应力场与酶活性之间的关系与二次抛物线一致，这为工业酶的工艺优化和规模放大提供了依据。生产。

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  • 来源
    《Bioprocess and Biosystems Engineering》 |2015年第5期|917-928|共12页
  • 作者

    Lu Hongzhong; Li Chao; Tang Wenjun; Wang Zejian; Xia Jianye; Zhang Siliang; Zhuang Yingping; Chu Ju; Noorman Henk;

  • 作者单位

    E China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;

    E China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;

    E China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;

    E China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;

    E China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;

    E China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;

    E China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;

    E China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;

    DSM Biotechnol Ctr, NL-2600 MA Delft, Netherlands;

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  • 原文格式 PDF
  • 正文语种 eng
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  • 关键词

    Aspergillus niger; Morphological control; Stirred tank; Mass transfer; Rheology; Hydrodynamics;

    机译：黑曲霉;形态控制;搅拌槽;传质;流变学;水动力;

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