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首页> 外文期刊>Bioprocess and Biosystems Engineering >Selective fengycin production in a modified rotating discs bioreactor
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Selective fengycin production in a modified rotating discs bioreactor

机译：改良型转盘式生物反应器中的选择性风霉素生产

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摘要

Production of lipopeptides fengycin and surf-actin in rotating discs bioreactor was studied. The effects of rotation velocity and the addition of agitators between the discs on volumetric oxygen transfer coefficient k_La were firstly studied in model media. Then the production of lipopeptides was also studied at different agitation conditions in the modified bioreactor (with agitators). The effect of agitation on dissolved oxygen, on submerged and immobilized biomass, on lipopeptide concentrations and yields and on the selectivity of the bioreaction was elucidated and discussed. The proposed modified rotating discs bioreactor allowed to obtain high fengycin concentrations (up to 787 mg L~(-1)), but also better selectivity of the bioreaction towards fengycin (up to 88 %) and better yields of fengycin per glucose (up to 62.9 mg g~(-1)), lipopeptides per glucose (up to 71.5 mg g~(-1)), fengycin per biomass (up to 309 mg g~(-1)) and lipopeptides per biomass (up to 396 mg g~(-1)) than those reported in the literature. Highest fengycin production and selectivity were obtained at agitation velocity of 30 min~(-1). The proposed non-foaming fermentation process could contribute to the scale-up of lipopeptide fermentors and promote the industrial production of fengycin. The proposed bioreactor and bioprocess could be very useful also for the production of other molecules using bioprocesses requiring bubbleless oxygen supply.
机译：研究了转盘生物反应器中脂肽丰霉素和表面肌动蛋白的产生。首先在模型介质中研究了旋转速度和圆盘之间搅拌器的添加对体积氧传递系数k_La的影响。然后，还研究了在改性生物反应器（带有搅拌器）中在不同搅拌条件下脂肽的产生。阐明并讨论了搅拌对溶解氧，对淹没和固定的生物量，脂肽浓度和产量以及生物反应选择性的影响。所提出的改进的旋转圆盘生物反应器允许获得高浓度的风霉素（高达787 mg L〜（-1）），而且对风霉素的生物反应的选择性更高（高达88％），并且每葡萄糖的风霉素产量更高（高达62.9 mg g〜（-1）），每个葡萄糖的脂肽（高达71.5 mg g〜（-1）），每个生物质的丰霉素（高达309 mg g〜（-1））和每个生物质的脂肽（高达396 mg） g〜（-1））。在30 min〜（-1）的搅拌速度下获得最高的丰霉素产量和选择性。拟议的非起泡发酵工艺可以促进脂肽发酵罐的规模化，并促进丰霉素的工业化生产。所提出的生物反应器和生物过程对于使用需要无气泡氧气供应的生物过程来生产其他分子也可能非常有用。

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  • 来源
    《Bioprocess and Biosystems Engineering》 |2014年第2期|107-114|共8页
  • 作者

    Omar Chtioui; Krasimir Dimitrov; Frederique Gancel; Pascal Dhulster; Iordan Nikov;

  • 作者单位

    Laboratoire des Precedes Biologiques, Genie Enzymatique et Microbien (ProBioGEM), UPRES-EA 1026, Polytech'Lille/IUT A, Universite Lille Nord de France, Avenue Paul Langevin, 59655 Villeneuve d'Ascq Cedex, France;

    Laboratoire des Precedes Biologiques, Genie Enzymatique et Microbien (ProBioGEM), UPRES-EA 1026, Polytech'Lille/IUT A, Universite Lille Nord de France, Avenue Paul Langevin, 59655 Villeneuve d'Ascq Cedex, France;

    Laboratoire des Precedes Biologiques, Genie Enzymatique et Microbien (ProBioGEM), UPRES-EA 1026, Polytech'Lille/IUT A, Universite Lille Nord de France, Avenue Paul Langevin, 59655 Villeneuve d'Ascq Cedex, France;

    Laboratoire des Precedes Biologiques, Genie Enzymatique et Microbien (ProBioGEM), UPRES-EA 1026, Polytech'Lille/IUT A, Universite Lille Nord de France, Avenue Paul Langevin, 59655 Villeneuve d'Ascq Cedex, France;

    Laboratoire des Precedes Biologiques, Genie Enzymatique et Microbien (ProBioGEM), UPRES-EA 1026, Polytech'Lille/IUT A, Universite Lille Nord de France, Avenue Paul Langevin, 59655 Villeneuve d'Ascq Cedex, France;

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  • 关键词

    Fengycin; Rotating discs bioreactor; Lipopeptides; Oxygen transfer; B. subtilis ATCC 21332;

    机译：凤霉素转盘生物反应器;脂肽;氧气转移;枯草芽孢杆菌ATCC 21332;

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