Applying dimorphic yeasts as model organisms to study mycelial growth: part 2. Use of mathematical simulations to identify different construction principles in yeast colonies

Thomas Walther; rnHolger Reinsch; rnKai Ostermann; rnAndreas Deutsch; rnThomas Bley

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Applying dimorphic yeasts as model organisms to study mycelial growth: part 2. Use of mathematical simulations to identify different construction principles in yeast colonies

机译：应用双态酵母作为模型生物研究菌丝体生长：第2部分。使用数学模拟识别酵母菌落中的不同构建原理

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The dimorphic yeasts Candida boidinii and Yarrowia lipolytica were applied as model organisms to study mycelial growth. A mathematical model of hybrid cellular automaton type was developed to analyze the impact of different biological assumptions on the predicted development of filamentous yeast colonies. The one-dimensional model described discrete cells and continuous distribution of nutrients. The simulation algorithm accounted for proliferation of cells, diffusion of nutrient, as well as biomass decay and recycling inside the mycelium. Simulations reproduced the spatio-temporal development of C. boidinii colonies when a diffusion-limited growth algorithm based on the growth of pseudohyphal cells was applied. Development of Y. lipolytica colonies could only be reproduced when proliferation was restricted to the colony boundary, and cell decay and biomass recycling were incorporated into the model. The results suggestedrnthat cytoplasm, which served as the secondary nutrient resource, had to be translocated inside the hyphal network.

机译：将双态酵母博伊丁假丝酵母和解脂耶氏酵母用作模型生物，以研究菌丝体的生长。建立了混合细胞自动机类型的数学模型，以分析不同生物学假设对丝状酵母菌落预测发展的影响。一维模型描述了离散的细胞和养分的连续分布。该模拟算法考虑了细胞的增殖，营养物的扩散以及生物质的降解和菌丝体内的再循环。当应用基于假菌丝细胞生长的扩散限制生长算法时，模拟再现了博伊丁酸梭菌菌落的时空发展。解脂耶氏酵母菌落的发展只有在增殖限制在菌落边界时才能复制，并且将细胞腐烂和生物质循环纳入模型。结果表明，作为次要营养资源的细胞质必须在菌丝网络内部转移。

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《Bioprocess and Biosystems Engineering》 |2011年第1期|p.21-31|共11页
作者
Thomas Walther; rnHolger Reinsch; rnKai Ostermann; rnAndreas Deutsch; rnThomas Bley;
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作者单位

Institute of Food Technology and Bioprocess Engineering,Technical University Dresden, 01062 Dresden, Germany Laboratoire d,Ingenierie des Systemes Biologiques et des Precedes, UMR INSA/CNRS 5504, UMR INSA/INRA 792, Institut National des Sciences Appliquees (INSA), 135 Avenue de Rangueil, 31077 Toulouse Cedex 04, France;

rnInstitute of Food Technology and Bioprocess Engineering,Technical University Dresden, 01062 Dresden, Germany;

rnInstitute of Genetics, Technical University Dresden,01062 Dresden, Germany;

rnCenter for Information Services and High Performance Computing, Technical University Dresden,01062 Dresden, Germany;

rnInstitute of Food Technology and Bioprocess Engineering,Technical University Dresden, 01062 Dresden, Germany;

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正文语种 eng
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cellular automaton model; yeast mycelia; nutrient translocation; biomass decay;

机译：元胞自动机模型酵母菌丝体营养素易位生物量衰减;

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1. Applying dimorphic yeasts as model organisms to study mycelial growth: Part 1. Experimental investigation of the spatio-temporal development of filamentous yeast colonies [J] . Thomas Walther, rnHolger Reinsch, rnPhilipp Weber, Bioprocess and Biosystems Engineering . 2011,第1期

机译：应用双态酵母作为模型生物研究菌丝体生长：第1部分。丝状酵母菌落时空发育的实验研究
2. A phosphatidylinositol/phosphatidylcholine transfer protein is required for differentiation of the dimorphic yeast Yarrowia lipolytica from the yeast to the mycelial form. [J] . M C Lopez, J M Nicaud, H B Skinner, Journal of cell biology . 1994,第1期

机译：磷脂酰肌醇/磷脂酰胆碱转移蛋白是双态酵母解脂耶氏酵母从酵母到菌丝体形式的分化所必需的。
3. A simple mathematical model that describes the growth of the area and the number of total and viable cells in yeast colonies [J] . Rivas E-M., Gil de Prado E., Wrent P., Letters in Applied Microbiology . 2014,第6期

机译：一个简单的数学模型，描述了酵母菌落的面积增长以及总细胞数和活细胞数
4. A global optimization strategy to identify quantitative design principles for gene expression in yeast adaptation to heat shock [C] . ESCAPE-19 . 2009

机译：一种全球优化策略，以鉴定酵母适应中基因表达的定量设计原理
5. Mathematical Models of Budding Yeast Colony Formation and Damage Segregation in Stem Cells [D] . Wang, Yanli. 2017

机译：干细胞萌芽酵母污染菌落形成的数学模型及损伤偏析
6. A phosphatidylinositol/phosphatidylcholine transfer protein is required for differentiation of the dimorphic yeast Yarrowia lipolytica from the yeast to the mycelial form [O] . 1994

机译：磷脂酰肌醇/磷脂酰胆碱转移蛋白是区分双形酵母解脂耶氏酵母从酵母到菌丝体形式的必需蛋白
7. A phosphatidylinositol/phosphatidylcholine transfer protein is required for differentiation of the dimorphic yeast Yarrowia lipolytica from the yeast to the mycelial form [O] . 1994

机译：磷脂酰肌醇/磷脂酰胆碱转移蛋白是区分双形酵母解脂耶氏酵母从酵母到菌丝体形式的必需蛋白

Applying dimorphic yeasts as model organisms to study mycelial growth: part 2. Use of mathematical simulations to identify different construction principles in yeast colonies

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