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Nonlinear PI controllers for continuous bioreactors using population balance models

机译：使用种群平衡模型的连续生物反应器非线性PI控制器

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摘要

Continuous bioreactors are critical unit operations in many biological systems, but the unique modeling is very complicated due to the underlying biochemical reactions and the distributed properties of cell population. The scope of this paper considers a popular modeling method for microbial cell cultures by population balance equation models, and the control objective aims to attenuate undesired oscillations appeared in the nonlinear distributed parameter system. In view of pursuing the popular/practical control configuration and the lack of on-line sensors, an approximate technique by exploiting the "pseudo-steady-state" approach constructs a simple nonlinear control model. Through an off-line estimation mechanism for the system having self-oscillating behavior, two kinds of nonlinear PI configurations are developed. Closed-loop simulation results have confirmed that the regulatory and tracking performances of the control system proposed are good.
机译：连续生物反应器是许多生物系统中至关重要的单元操作，但是由于潜在的生化反应和细胞群的分布特性，独特的建模非常复杂。本文的范围考虑了通过种群平衡方程模型对微生物细胞培养进行建模的一种流行方法，其控制目标旨在衰减非线性分布参数系统中出现的不希望有的振荡。鉴于追求流行的/实用的控制配置以及缺少在线传感器，通过利用“伪稳态”方法的近似技术构造了简单的非线性控制模型。通过针对具有自激行为的系统的离线估计机制，开发了两种非线性PI配置。闭环仿真结果已经证实所提出的控制系统的调节和跟踪性能良好。

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